{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:51:39Z","timestamp":1791298299910,"version":"4.1.0"},"reference-count":92,"publisher":"Wiley","issue":"S22","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Considering the role of the inflammatory host response in the pathogenesis of periodontitis, different host modulators have been proposed to enhance the outcomes of non\u2010surgical periodontal therapy (NSPT), but their efficacy has not been fully clarified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This systematic review investigated the efficacy of host modulators combined with NSPT in reducing probing pocket depth (PPD) in periodontitis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and methods<\/jats:title>\n                    <jats:p>Placebo\u2010controlled RCTs with \u22656\u00a0months follow\u2010up were searched. Meta\u2010analysis was conducted when \u22655 studies using the same host modulator were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Fifty eight studies met the inclusion criteria. After 6\u00a0months, local administration of 1.2% statin gels as adjuncts to NSPT significantly improved PPD reduction (1.83\u00a0mm) in infrabony defects and systemic administration of sub\u2010antimicrobial dose doxycycline (SDD) in addition to NSPT improved PPD reduction of deep pockets. Administration of probiotics conferred limited clinical benefits. Local bisphosphonate and metformin gels showed potential for clinical use in infrabony defects, which needs to be confirmed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Local delivery of statins in infrabony defects and systemic SDD for deep pockets may confer additional clinical benefits to NSPT. Their long\u2010term effectiveness and safety\u00a0need to be confirmed in independent multi\u2010centred studies. Further studies are needed to confirm the benefit of other\u00a0host modulators.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.13232","type":"journal-article","created":{"date-parts":[[2019,12,13]],"date-time":"2019-12-13T13:01:02Z","timestamp":1576242062000},"page":"199-238","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":139,"title":["The adjunctive use of host modulators in non\u2010surgical periodontal therapy. 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