{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T19:30:20Z","timestamp":1791747020270,"version":"4.3.4"},"reference-count":83,"publisher":"Wiley","issue":"S22","license":[{"start":{"date-parts":[[2020,7,27]],"date-time":"2020-07-27T00:00:00Z","timestamp":1595808000000},"content-version":"vor","delay-in-days":26,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To compare the adjunctive effects of lasers or antimicrobial photodynamic therapy (aPDT) to non\u2010surgical mechanical instrumentation alone in untreated periodontitis patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Two focused questions were addressed using the Population, Intervention, Comparison and Outcome criteria as follows: in patients with untreated periodontitis, (a) does laser application provide adjunctive effects on probing pocket depth (PPD) changes compared with non\u2010surgical instrumentation alone? and (b) does application of aPDT provide adjunctive effects on PPD changes compared with non\u2010surgical instrumentation alone? Both randomized controlled clinical trials (RCTs) and controlled clinical trials (CCTs) were included. Results of the meta\u2010analysis are expressed as weighted mean differences (WMD) and reported according to the PRISMA guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Out of 1,202 records, 10 articles for adjunctive laser and 8 for adjunctive aPDT were included. With respect to PPD changes, 1 meta\u2010analysis including 2 articles (total\n                      <jats:italic>n<\/jats:italic>\n                      \u00a0=\u00a042; split\u2010mouth design) failed to identify a statistically significant difference (WMD\u00a0=\u00a00.35\u00a0mm; 95%CI: \u22120.04\/0.73;\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0=\u00a0.08) in favour of adjunctive aPDT (wavelength range 650\u2013700\u00a0nm). In terms of adjunctive laser application, a high variability of clinical outcomes at 6\u00a0months was noted. Two articles included patient\u2010reported outcomes and 10 reported on the presence\/absence of harms\/adverse effects.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Available evidence on adjunctive therapy with lasers and aPDT is limited by (a) the low number of controlled studies and (b) the heterogeneity of study designs. Patient\u2010reported benefits remain to be demonstrated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.13236","type":"journal-article","created":{"date-parts":[[2019,12,20]],"date-time":"2019-12-20T08:20:22Z","timestamp":1576830022000},"page":"176-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":151,"title":["Adjunctive laser or antimicrobial photodynamic therapy to non\u2010surgical mechanical instrumentation in patients with untreated periodontitis: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5523-3192","authenticated-orcid":false,"given":"Giovanni E.","family":"Salvi","sequence":"first","affiliation":[{"name":"Department of Periodontology School of Dental Medicine University of Bern Bern 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