{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T11:48:51Z","timestamp":1791892131811,"version":"4.3.4"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T00:00:00Z","timestamp":1581379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008347","name":"Bezmialem Vakif \u00dcniversitesi","doi-asserted-by":"publisher","award":["6.2017\/18"],"award-info":[{"award-number":["6.2017\/18"]}],"id":[{"id":"10.13039\/501100008347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this present study was to evaluate the effect of gingival thickness (GT) and keratinized tissue width (KTW)\u00a0using injectable platelet\u2010rich fibrin (i\u2010PRF) alone and with microneedling (MN) in individuals with thin periodontal phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this split\u2010mouth study, 33 systemically healthy patients with thin periodontal phenotypes were randomly treated with MN\u00a0+\u00a0i\u2010PRF and i\u2010PRF. I\u2010PRF was injected on one side, and MN\u00a0+\u00a0i\u2010PRF was performed on the other side of the same patient at 4 sessions with 10\u2010day intervals. Clinical periodontal measurements, GT and KTW\u00a0were assessed before the treatment and every month for six months after the final injection.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the evaluation of GT between the groups, a statistically significant difference was found in MN\u00a0+\u00a0i\u2010PRF group at the sixth month. In the intra\u2010group comparisons, a statistically significant increase in GT was observed within both i\u2010PRF [from 0.43\u00a0mm\u00a0\u00b1\u00a00.14 to\u00a00.62\u00a0mm\u00a0\u00b1\u00a00.11 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001)] and MN\u00a0+\u00a0i\u2010PRF [from 0.4\u00a0mm\u00a0\u00b1\u00a00.14 to 0.66\u00a0mm\u00a0\u00b1\u00a00.12 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001)] groups at the sixth month.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In individuals with thin periodontal phenotypes, standalone i\u2010PRF and i\u2010PRF with MN may have an influence in increasing GT. The results suggest that application of i\u2010PRF and MN may be a first step of non\u2010surgical method for increasing gingival thickness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13247","type":"journal-article","created":{"date-parts":[[2020,1,8]],"date-time":"2020-01-08T02:40:28Z","timestamp":1578451228000},"page":"489-499","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Injectable platelet\u2010rich fibrin and microneedling for gingival augmentation in thin periodontal phenotype: A randomized controlled clinical trial"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7067-5263","authenticated-orcid":false,"given":"Zeliha Betul","family":"Ozsagir","sequence":"first","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Bezmialem Vakif University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7329-8085","authenticated-orcid":false,"given":"Ebru","family":"Saglam","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry University of Health Science Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7961-0535","authenticated-orcid":false,"given":"Berza","family":"Sen Yilmaz","sequence":"additional","affiliation":[{"name":"Department of Orthodontics Faculty of Dentistry Bezmialem University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4466-5149","authenticated-orcid":false,"given":"Joseph","family":"Choukroun","sequence":"additional","affiliation":[{"name":"FORM Frankfurt Oral Regenerative Medicine Clinic for Maxillofacial and Plastic Surgery Johann Wolfgang Goethe University Frankfurt am Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1251-3431","authenticated-orcid":false,"given":"Mustafa","family":"Tunali","sequence":"additional","affiliation":[{"name":"Department of Periodontology Faculty of Dentistry Bezmialem Vakif University Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,11]]},"reference":[{"issue":"4","key":"e_1_2_8_2_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000001248"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.prs.0000304612.72899.02"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.burns.2009.11.014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjps.2010.03.038"},{"key":"e_1_2_8_7_1","first-page":"1","article-title":"Medical needling: Improving the appearance of hyperthrophic burn\u2010scars","volume":"3","author":"Aust M. 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