{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:32:07Z","timestamp":1790188327669,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T00:00:00Z","timestamp":1580688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>This study compared the clinical efficacy of the entire papilla preservation technique (EPP) alone and in combination with enamel matrix proteins plus bovine\u2010derived bone substitutes (EPP EMD\u00a0+\u00a0BS) in the treatment of isolated inter\u2010dental intrabony defects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and methods<\/jats:title>\n                    <jats:p>Thirty patients, each with one isolated intrabony defect, were randomly assigned to EPP EMD\u00a0+\u00a0BS or EPP alone. Clinical outcomes were assessed 1\u2010year post\u2010surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Early healing phase was uneventful in all cases, and 100% primary wound closure was maintained throughout the study period. Intragroup differences between baseline and 1\u2010year were statistically significant in both groups in terms of clinical attachment level (CAL) gain and probing depth (PD) reduction (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0\u2264\u00a0.001). No statistically significant differences were detected in gingival recession (REC) (\n                      <jats:italic>p<\/jats:italic>\n                      \u00a0&gt;\u00a0.05). No statistically significant differences were detected in terms of CAL gain (6.3\u00a0\u00b1\u00a02.5\u00a0mm vs. 5.83\u00a0\u00b1\u00a01.12\u00a0mm), PD reduction (6.5\u00a0\u00b1\u00a02.65\u00a0mm vs. 6.2\u00a0\u00b1\u00a01.33\u00a0mm) or increase in gingival recession (0.2\u00a0\u00b1\u00a00.25\u00a0mm vs. 0.36\u00a0\u00b1\u00a00.54\u00a0mm) between the groups treated with EPP EMD\u00a0+\u00a0BS or EPP alone.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Application of EPP with and without regenerative biomaterials resulted in significant amounts of CAL gain and PD reduction, with negligible increase in gingival recession. Within the limits of the present study, it can be concluded that the addition of regenerative biomaterials does not improve the clinical outcomes of EPP alone. NCT03923465.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.13255","type":"journal-article","created":{"date-parts":[[2020,1,11]],"date-time":"2020-01-11T02:39:26Z","timestamp":1578710366000},"page":"470-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Clinical outcomes of the entire papilla preservation technique with and without biomaterials in the treatment of isolated intrabony defects: A randomized controlled clinical trial"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6102-686X","authenticated-orcid":false,"given":"Serhat","family":"Aslan","sequence":"first","affiliation":[{"name":"Private Office Dr. Aslan \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1590-5801","authenticated-orcid":false,"given":"Nurcan","family":"Buduneli","sequence":"additional","affiliation":[{"name":"Department of Periodontology School of Dentistry Ege University \u0130zmir Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierpaolo","family":"Cortellini","sequence":"additional","affiliation":[{"name":"Accademia Toscana di Ricerca Odontostomatologica (ATRO) Florence Italy"},{"name":"European Research Group on Periodontology (ERGOPERIO) Berne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,3]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.2584"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12780"},{"key":"e_1_2_9_4_1","first-page":"109","article-title":"Periodontal regeneration with an autogenous bone\u2010Bio\u2010Oss composite graft and a Bio\u2010Gide membrane","volume":"21","author":"Camelo M.","year":"2001","journal-title":"International Journal of Periodontics & Restorative Dentistry"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1532-3382(12)70021-0"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12638"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.4.254"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.9.797"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.4.261"},{"key":"e_1_2_9_10_1","first-page":"589","article-title":"The simplified papilla preservation flap. 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