{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,10]],"date-time":"2026-01-10T00:26:29Z","timestamp":1768004789466,"version":"3.49.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,12]],"date-time":"2020-03-12T00:00:00Z","timestamp":1583971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Institut Straumann AG"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this study was to compare surgical treatment of periodontal intra\u2010bony defects (IBD) with or without the adjunct of enamel matrix derivative (EMD) in terms of acute\u2010phase responses in healthy patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010eight periodontitis\u2010affected subjects, one IDB each, were randomized to minimally invasive periodontal surgery (MIS) with or without EMD. Periodontal parameters were recorded at baseline and 6\u2010months. Blood samples were collected at baseline, 1, 7 and 180\u00a0days after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 24\u00a0hr, the group treated MIS with EMD showed lower values of C\u2010reactive protein (CRP; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01) as no inflammatory perturbation was noticed. Conversely, MIS group resulted in an acute inflammatory response at 24\u00a0hr (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) that regressed to its baseline values at day 7. The EMD group showed a higher number of cases without residual BOP or PPD\u00a0\u2265\u00a05mm 6\u00a0months after surgery (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), and post\u2010surgical gingival recession was lower (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The adjunctive application of EMD during surgical treatment resulted in a minor increase in serum CRP 24\u2010hr after surgery. These findings suggest a possible systemic anti\u2010inflammatory effect of EMD. Within its limitations, this pilot trial confirmed better clinical periodontal outcomes in the EMD group. 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