{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T20:30:40Z","timestamp":1791923440511,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000377","name":"Dunhill Medical Trust","doi-asserted-by":"publisher","award":["R63\/1107"],"award-info":[{"award-number":["R63\/1107"]}],"id":[{"id":"10.13039\/501100000377","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","award":["DHCS\/03\/G121\/46"],"award-info":[{"award-number":["DHCS\/03\/G121\/46"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To assess the impact of periodontal treatment on systemic inflammation in type 2 diabetes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Adults with type 2 diabetes (<jats:italic>n<\/jats:italic>\u00a0=\u00a083) and without diabetes (controls, <jats:italic>n<\/jats:italic>\u00a0=\u00a075) were recruited, and participants with periodontitis received periodontal treatment and 12\u00a0months\u2019 follow\u2010up. Biomarkers for periodontal inflammation (gingival crevicular fluid interleukin\u20106, tumour necrosis factor\u2010\u03b1, interleukin\u20101\u03b2, interferon\u2010\u03b3, matrix metalloproteinase\u20108, matrix metalloproteinase\u20109, adiponectin) and serum markers of inflammation and diabetes control (glycated haemoglobin, high sensitivity C\u2010reactive protein, interleukin\u20106, tumour necrosis factor\u2010\u03b1, interleukin\u20101\u03b2, interferon\u2010\u03b3, leptin, adiponectin) were measured. Structural equation modelling was used to evaluate periodontal treatment effects on oral and systemic inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Periodontal treatment resulted in significant improvements in clinical status and reductions in gingival crevicular fluid biomarkers from baseline to month 12. Structural equation modelling identified that, at baseline, individuals with diabetes and periodontitis had significantly higher systemic inflammation than non\u2010diabetic controls with periodontitis (\u0394\u00a0=\u00a00.20, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002), with no significant differences between groups for oral inflammation. There was a greater reduction in systemic inflammation following periodontal treatment in individuals with diabetes and periodontitis compared to those with periodontitis but not diabetes (\u0394\u00a0=\u00a0\u22120.25, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diabetes and periodontitis together appear to increase systemic inflammation, with evidence of reductions following periodontal treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13274","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T17:37:27Z","timestamp":1582825047000},"page":"737-746","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":88,"title":["Treatment of periodontitis reduces systemic inflammation in type 2 diabetes"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7153-4865","authenticated-orcid":false,"given":"Philip M.","family":"Preshaw","sequence":"first","affiliation":[{"name":"School of Dental Sciences Newcastle University Newcastle upon Tyne UK"},{"name":"Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Taylor","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University Newcastle upon Tyne UK"},{"name":"Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katrin M.","family":"Jaedicke","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University Newcastle upon Tyne UK"},{"name":"Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2767-5361","authenticated-orcid":false,"given":"Marko","family":"De Jager","sequence":"additional","affiliation":[{"name":"Philips Research Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Willem","family":"Bikker","sequence":"additional","affiliation":[{"name":"Consultants in Quantitative Methods Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wieke","family":"Selten","sequence":"additional","affiliation":[{"name":"Consultants in Quantitative Methods Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan M.","family":"Bissett","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University Newcastle upon Tyne UK"},{"name":"Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerry M.","family":"Whall","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"van de Merwe","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University Newcastle upon Tyne UK"},{"name":"Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Areibi","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University Newcastle upon Tyne UK"},{"name":"Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paiboon","family":"Jitprasertwong","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University Newcastle upon Tyne UK"},{"name":"Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rana","family":"Al\u2010Shahwani","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University Newcastle upon Tyne UK"},{"name":"Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jolanta","family":"Weaver","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Taylor","sequence":"additional","affiliation":[{"name":"Institute of Cellular Medicine Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca R.","family":"Wassall","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University Newcastle upon Tyne UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,5,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12080"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12517"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12077"},{"issue":"2","key":"e_1_2_8_6_1","first-page":"6","article-title":"Clinical significance of non\u2010surgical periodontal therapy: An evidence\u2010based perspective of scaling and root planing","volume":"29","author":"Cobb C. M.","year":"2002","journal-title":"Journal of Clinical Periodontology"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30038-X"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12084"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034519857714"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.150727"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12837"},{"key":"e_1_2_8_12_1","volume-title":"IDF diabetes atlas","author":"International Diabetes Federation","year":"2019"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910508401212"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2009.090267"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-010-0248-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034514552491"},{"key":"e_1_2_8_17_1","volume-title":"Principles and practice of structural equation modelling","author":"Kline R. B.","year":"2011"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.29.02.06.dc05-1355"},{"key":"e_1_2_8_19_1","first-page":"3","article-title":"A modified gingival index for use in clinical trials","volume":"8","author":"Lobene R. R.","year":"1986","journal-title":"Clinical Preventive Dentistry"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12836"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2007.01127.x"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12803"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-011-2342-y"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01624.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12808"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2017.12.001"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.2337\/diacare.28.1.27"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1184"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016356408993968"},{"key":"e_1_2_8_30_1","first-page":"CD004714","article-title":"Treatment of periodontal disease for glycaemic control in people with diabetes","author":"Simpson T. C.","year":"2010","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_8_31_1","first-page":"CD004714","article-title":"Treatment of periodontal disease for glycaemic control in people with diabetes mellitus","author":"Simpson T. C.","year":"2015","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12059"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12171"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa063186"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12109"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjcpe.13274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13274","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpe.13274","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13274","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T08:45:33Z","timestamp":1693989933000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.13274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,12]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,6]]}},"alternative-id":["10.1111\/jcpe.13274"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.13274","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,5,12]]},"assertion":[{"value":"2019-11-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}