{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:09:08Z","timestamp":1785856148326,"version":"3.56.0"},"reference-count":65,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate clinical and biochemical effects of adjunctive systemic folic acid (FA) intake with scaling and root planing (SRP) in periodontitis treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Sixty periodontitis subjects (30 per group) were randomly assigned into study groups and treated with either SRP\u00a0+\u00a0placebo (SRP\u00a0+\u00a0P) or SRP\u00a0+\u00a0folic acid (SRP\u00a0+\u00a0F). In addition to clinical parameters (plaque index [PI], gingival index [GI], probing pocket depth [PPD], clinical attachment level [CAL] and gingival recession [GR]), gingival crevicular fluid (GCF) samples were obtained at baseline and post\u2010treatment (PT) periods (one (PT\u20101), three (PT\u20103) and six (PT\u20106) months) for C\u2010reactive protein (CRP) and homocysteine (Hcy) evaluation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant time\u2010dependent reduction was detected at all clinical parameters for both groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Compared to SRP\u00a0+\u00a0P, CAL was lower in SRP\u00a0+\u00a0F at PT\u20101 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.004) and PT\u20103 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.035), whereas GR was lower at only PT\u20101 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.015). GCF volume and CRP did not show inter\u2010group differences, whereas Hcy was higher in SRP\u00a0+\u00a0F at PT\u20103 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.044) and PT\u20106 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.041). GCF volume and Hcy showed reduction after treatment in both groups (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Both modalities exhibited clinical improvement and change in biochemical parameters. Adjunctive systemic FA intake may be recommended adjunctive to periodontitis treatment to reveal better outcomes. However, its impact mechanisms should be further enlightened.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13276","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T14:02:26Z","timestamp":1582898546000},"page":"602-613","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["The effect of the systemic folic acid intake as an adjunct to scaling and root planing on clinical parameters and homocysteine and C\u2010reactive protein levels in gingival crevicular fluid of periodontitis patients: A randomized placebo\u2010controlled clinical trial"],"prefix":"10.1111","volume":"47","author":[{"given":"H. 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