{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T04:01:28Z","timestamp":1793160088043,"version":"4.5.0"},"reference-count":51,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,3]],"date-time":"2020-04-03T00:00:00Z","timestamp":1585872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002850","name":"Fondo Nacional de Desarrollo Cient\u00edfico y Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["FONDECYT 1181780"],"award-info":[{"award-number":["FONDECYT 1181780"]}],"id":[{"id":"10.13039\/501100002850","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>T lymphocytes play a central role during the pathogenesis of periodontitis, and the imbalance between the pathogenic T\u2010helper type 17 (Th17) and protective T\u2010regulatory (Treg) lymphocytes determines the tooth\u2010supporting alveolar bone resorption. Interleukin (IL)\u201035 is a novel anti\u2010inflammatory cytokine with therapeutic properties in diseases whose pathogenesis is associated with the Th17\/Treg imbalance; however, its role during periodontitis has not been established yet. This study aimed to elucidate whether IL\u201035 inhibits the alveolar bone resorption during periodontitis by modulating the Th17\/Treg imbalance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Mice with ligature\u2010induced periodontitis were treated with locally or systemically administrated IL\u201035. As controls, periodontitis\u2010affected mice without IL\u201035 treatment and non\u2010ligated mice were used. Alveolar bone resorption was measured by micro\u2010computed tomography and scanning electron microscopy. The Th17\/Treg pattern of the immune response was analysed by qPCR, ELISA, and flow cytometry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>IL\u201035 inhibited alveolar bone resorption in periodontitis mice. Besides, IL\u201035 induced less detection of Th17 lymphocytes and production of Th17\u2010related cytokines, together with higher detection of Treg lymphocytes and production of Treg\u2010related cytokines in periodontitis\u2010affected tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IL\u201035 is beneficial in the regulation of periodontitis; particularly, IL\u201035 inhibited alveolar bone resorption and this inhibition was closely associated with modulation of the periodontal Th17\/Treg imbalance.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13282","type":"journal-article","created":{"date-parts":[[2020,3,11]],"date-time":"2020-03-11T16:47:34Z","timestamp":1583945254000},"page":"676-688","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Interleukin\u201035 inhibits alveolar bone resorption by modulating the Th17\/Treg imbalance during 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