{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T17:05:15Z","timestamp":1793293515683,"version":"4.5.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T00:00:00Z","timestamp":1587340800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003758","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa e ao Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico do Maranh\u00e3o","doi-asserted-by":"crossref","award":["APP N\u00ba00540\/2012"],"award-info":[{"award-number":["APP N\u00ba00540\/2012"]}],"id":[{"id":"10.13039\/501100003758","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the association among iron overload, periodontal status, and periodontitis progression rate in sickle cell anaemia (SCA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>This case series evaluated 123 patients. Clinical attachment level (CAL) and probing depth (PD) were evaluated at six sites per tooth. Alveolar bone loss was estimated using periapical radiography. Study outcomes were periodontal status (measured as number of sites with CAL of \u22653\u00a0mm, CAL of \u22655\u00a0mm, PD of \u22654\u00a0mm, and PD of \u22656\u00a0mm) and periodontitis progression rate (determined as ratio of alveolar bone loss to age). Serum transferrin saturation and ferritin levels were obtained from medical records. Poisson regression was performed to estimate associations. Covariables included in the adjusted models (comorbidities, skin colour, socioeconomic class, and vaso\u2010occlusive crisis) were defined by DAGs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Serum transferrin saturation level revealed a significant positive association with the number of sites with CAL of \u22653\u00a0mm, CAL of \u22655\u00a0mm, PD of \u22654\u00a0mm, and PD of \u22656\u00a0mm. Patients with serum transferrin saturation level of &gt;45% were 1.93 times more likely to have rapid periodontitis progression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>High serum transferrin saturation level is associated with a greater extent of periodontitis and rapid periodontitis progression in SCA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13284","type":"journal-article","created":{"date-parts":[[2020,3,19]],"date-time":"2020-03-19T06:54:58Z","timestamp":1584600898000},"page":"668-675","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Iron overload and periodontal status in patients with sickle cell anaemia: A case series"],"prefix":"10.1111","volume":"47","author":[{"given":"Susilena Arouche","family":"Costa","sequence":"first","affiliation":[{"name":"Postgraduate Dentistry Program Federal University of Maranh\u00e3o S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3756-2675","authenticated-orcid":false,"given":"Ana Regina Oliveira","family":"Moreira","sequence":"additional","affiliation":[{"name":"Dentistry Federal University of Maranh\u00e3o S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyrene Piazera Silva","family":"Costa","sequence":"additional","affiliation":[{"name":"Dentistry Federal University of Maranh\u00e3o S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8730-8600","authenticated-orcid":false,"given":"Soraia de F\u00e1tima","family":"Carvalho Souza","sequence":"additional","affiliation":[{"name":"Department of Dentistry Federal University of Maranh\u00e3o S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,4,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1992.tb00447.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.13180"},{"key":"e_1_2_8_4_1","first-page":"1","volume-title":"Crit\u00e9rio De Classifica\u00e7\u00e3o Econ\u00f4mica Brasil","author":"Associa\u00e7\u00e3o Brasileira de Empresas de Pesquisa","year":"2016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0037-1963(01)90058-7"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.15811"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33813-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12018"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2013.1.439"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12342"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.67.2.576-580.1999"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2010.156802"},{"key":"e_1_2_8_13_1","first-page":"CD012082","article-title":"Red blood cell transfusion to treat or prevent complications in sickle cell disease: An overview of Cochrane reviews","volume":"8","author":"Fortin P. 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