{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T17:37:47Z","timestamp":1778175467692,"version":"3.51.4"},"reference-count":59,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T00:00:00Z","timestamp":1586649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Instituto de Salud Carlos III (General Division of Evaluation and Research Promotion, Madrid, Spain) and co-financed by FEDER","award":["ISCIII\/PI17\/01722"],"award-info":[{"award-number":["ISCIII\/PI17\/01722"]}]},{"name":"the Conseller\u00eda de Cultura, Educaci\u00f3n e Ordenaci\u00f3n Universitaria da Xunta de Galicia","award":["ED431B 2017\/029"],"award-info":[{"award-number":["ED431B 2017\/029"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To obtain salivary interleukin (IL) 1\u03b2\u2010based models to predict the probability of the occurrence of periodontitis, differentiating by smoking habit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials\/Methods<\/jats:title><jats:p>A total of 141 participants were recruited, 62 periodontally healthy controls and 79 subjects affected by periodontitis. Fifty of the diseased patients were given non\u2010surgical periodontal treatment and showed significant clinical improvement in 2\u00a0months. IL1\u03b2 was measured in the salivary samples using the Luminex instrument. Binary logistic regression models were obtained to differentiate untreated periodontitis from periodontal health (first modelling) and untreated periodontitis from treated periodontitis (second modelling), distinguishing between non\u2010smokers and smokers. The area under the curve (AUC) and classification measures were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the first modelling, IL1\u03b2 presented AUC values of 0.830 for non\u2010smokers and 0.689 for smokers (accuracy\u00a0=\u00a077.6% and 70.7%, respectively). In the second, the predictive models revealed AUC values of 0.671 for non\u2010smokers and 0.708 for smokers (accuracy\u00a0=\u00a070.0% and 75.0%, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Salivary IL1\u03b2 has an excellent diagnostic capability when it comes to distinguishing systemically healthy patients with untreated periodontitis from those who are periodontally healthy, although this discriminatory potential is reduced in smokers. The diagnostic capacity of salivary IL1\u03b2 remains acceptable for differentiating between untreated and treated periodontitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13285","type":"journal-article","created":{"date-parts":[[2020,3,21]],"date-time":"2020-03-21T09:14:08Z","timestamp":1584782048000},"page":"702-714","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Diagnostic accuracy of IL1\u03b2 in saliva: The development of predictive models for estimating the probability of the occurrence of periodontitis in non\u2010smokers and smokers"],"prefix":"10.1111","volume":"47","author":[{"given":"Nora","family":"Arias\u2010Bujanda","sequence":"first","affiliation":[{"name":"Oral Sciences Research Group Special Needs Unit Department of Surgery and Medical\u2010surgical Specialties School of Medicine and Dentistry Health Research Institute Foundation of Santiago (FIDIS) Universidade de Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alba","family":"Regueira\u2010Iglesias","sequence":"additional","affiliation":[{"name":"Oral Sciences Research Group Special Needs Unit Department of Surgery and Medical\u2010surgical Specialties School of Medicine and Dentistry Health Research Institute Foundation of Santiago (FIDIS) Universidade de Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Triana","family":"Blanco\u2010Pintos","sequence":"additional","affiliation":[{"name":"Oral Sciences Research Group Special Needs Unit Department of Surgery and Medical\u2010surgical Specialties School of Medicine and Dentistry Health Research Institute Foundation of Santiago (FIDIS) Universidade de Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0916-4672","authenticated-orcid":false,"given":"Manuela","family":"Alonso-Sampedro","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine and Clinical Epidemiology Complejo Hospitalario Universitario Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0713-2041","authenticated-orcid":false,"given":"Marta","family":"Relvas","sequence":"additional","affiliation":[{"name":"Instituto Universit\u00e1rio de Ci\u00eancias da Sa\u00fade\u2010Norte Centro de Investiga\u00e7\u00e3o de Ci\u00eancias da Sa\u00fade Gandra Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Mercedes","family":"Gonz\u00e1lez\u2010Peteiro","sequence":"additional","affiliation":[{"name":"Oral Sciences Research Group Special Needs Unit Department of Surgery and Medical\u2010surgical Specialties School of Medicine and Dentistry Health Research Institute Foundation of Santiago (FIDIS) Universidade de Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7937-6673","authenticated-orcid":false,"given":"Carlos","family":"Balsa\u2010Castro","sequence":"additional","affiliation":[{"name":"Oral Sciences Research Group Special Needs Unit Department of Surgery and Medical\u2010surgical Specialties School of Medicine and Dentistry Health Research Institute Foundation of Santiago (FIDIS) Universidade de Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3317-0853","authenticated-orcid":false,"given":"Inmaculada","family":"Tom\u00e1s","sequence":"additional","affiliation":[{"name":"Oral Sciences Research Group Special Needs Unit Department of Surgery and Medical\u2010surgical Specialties School of Medicine and Dentistry Health Research Institute Foundation of Santiago (FIDIS) Universidade de Santiago de Compostela Santiago de Compostela Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160196"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170245"},{"issue":"5","key":"e_1_2_7_4_1","first-page":"1306396","article-title":"The ability of quantitative, specific, and sensitive point\u2010of\u2010care\/chair\u2010side oral fluid immunotests for aMMP\u20108 to detect periodontal and peri\u2010implant diseases","volume":"2018","author":"Alassiri S.","year":"2018","journal-title":"Disease Markers"},{"issue":"4","key":"e_1_2_7_5_1","first-page":"95","article-title":"Oral fluid based biomarkers in periodontal disease: Part 1. 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