{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T08:13:32Z","timestamp":1792397612826,"version":"4.4.0"},"reference-count":46,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,29]],"date-time":"2020-06-29T00:00:00Z","timestamp":1593388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate effects of probiotic <jats:italic>Lactobacillus reuteri<\/jats:italic> (<jats:italic>L. reuteri<\/jats:italic>) lozenges as an S\/RSD adjunct on site\u2010level changes at molars with deep pockets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>447 molar sites with pockets\u00a0\u2265\u00a05\u00a0mm from a previous randomized clinical trial of adjunctive <jats:italic>L. reuteri<\/jats:italic> lozenges for 28\u00a0days were analyzed. Multilevel mixed\u2010effect models (MLM) were constructed to analyze site\u2010level outcomes \u201cchange in CAL\u201d and \u201cpocket closure\u201d (residual PPD\u00a0&lt;\u00a05\u00a0mm) in placebo and probiotic groups at 90 and 180\u00a0days. Possible patient\u2010, tooth\u2010, and site\u2010level predictors were analyzed as fixed\u2010effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Estimated change in CAL in probiotic (90\u00a0day: 0.87\u00a0mm, 180\u00a0day: 0.68\u00a0mm) was greater than placebo treated molar sites (90\u00a0day: 0.73\u00a0mm, 180\u00a0day: 0.66\u00a0mm) and the relative risk (RR) of pocket closure in the probiotic group (90\u00a0day: 1.7, 180\u00a0day: 1.6) was higher as compared to placebo. Furcation involvement and BOP at site predicted significantly worse treatment outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>As compared to S\/RSD with placebo, a 28\u2010day course of adjunctive probiotic <jats:italic>L. reuteri<\/jats:italic> lozenges improved CAL change at molar sites with\u00a0\u2265\u00a05\u00a0mm deep pockets and conferred a higher probability of shallow residual pocket depth. Presence of furcation\u2010involvement and bleeding on probing worsened treatment outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13329","type":"journal-article","created":{"date-parts":[[2020,6,8]],"date-time":"2020-06-08T20:54:43Z","timestamp":1591649683000},"page":"1098-1107","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effects of adjunctive probiotic <i>L. reuteri<\/i> lozenges on S\/RSD outcomes at molar sites with deep pockets"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1917-1988","authenticated-orcid":false,"given":"Georgios","family":"Pelekos","sequence":"first","affiliation":[{"name":"Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9319-6780","authenticated-orcid":false,"given":"Aneesha","family":"Acharya","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry The University of Hong Kong Hong Kong SAR China"},{"name":"Dr. D.Y. 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