{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:58:55Z","timestamp":1790395135214,"version":"4.1.0"},"reference-count":60,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T00:00:00Z","timestamp":1593129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>The primary aim of this investigation was to analyse the periodontal microbiome in patients with aggressive periodontitis (AgP) following treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010six AgP patients were recalled on average 7\u00a0years after completion of active periodontal treatment and had subgingival plaque samples collected and processed for 16S rRNA gene sequencing analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 66 participants, 52 showed persistent periodontal disease, while 13 participants were considered as \u201csuccessfully treated AgP\u201d (no probing pocket depths &gt;4\u00a0mm) and 1 was fully edentulous. Genera associated with persistent generalized disease included <jats:italic>Actinomyces<\/jats:italic>,<jats:italic> Alloprevotella, Capnocytophaga, Filifactor, Fretibacterium, Fusobacterium, Leptotrichia, Mogibacterium, Saccharibacteria [G\u20101], Selenomonas and Treponema<\/jats:italic>. \u201cSuccessfully treated\u201d patients harboured higher proportions of <jats:italic>Haemophilus, Rothia, and Lautropia<\/jats:italic> and of <jats:italic>Corynebacterium, Streptococcus<\/jats:italic> and <jats:italic>Peptidiphaga<\/jats:italic> genera. Overall, patients with persistent generalized AgP (GAgP) revealed higher alpha diversity compared to persistent localized AgP (LAgP) and stable patients (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001). Beta diversity analyses revealed significant differences only between stable and persistent GAgP groups (<jats:italic>p\u00a0=\u00a0<\/jats:italic>.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients with persistent AgP showed a more dysbiotic subgingival biofilm than those who have been successfully treated. It remains to be established whether such differences were predisposing to disease activity or were a result of a dysbiotic change associated with disease recurrence in the presence of sub\u2010standard supportive periodontal therapy or other patient\u2010related factors.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13330","type":"journal-article","created":{"date-parts":[[2020,6,17]],"date-time":"2020-06-17T21:59:46Z","timestamp":1592431186000},"page":"980-990","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Differences in the periodontal microbiome of successfully treated and persistent aggressive periodontitis"],"prefix":"10.1111","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-5010","authenticated-orcid":false,"given":"Luigi","family":"Nibali","sequence":"first","affiliation":[{"name":"Periodontology Unit, Centre for Host Microbiome Interactions, Faculty of Dentistry, Oral &amp; 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