{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:35:58Z","timestamp":1792020958605,"version":"4.4.0"},"reference-count":72,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,17]],"date-time":"2020-11-17T00:00:00Z","timestamp":1605571200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Salivary biomarkers can help in assessment of periodontitis; however, concentrations may be altered in the presence of diabetes. Hence, the ability of salivary biomarkers to discriminate periodontally healthy type II diabetics (T2DM) from T2DM who have periodontitis was examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety\u2010two participants (29 with T2DM with chronic periodontitis, DWP; 32 T2DM without chronic periodontitis, DWoP; and 31 Not Periodontitis, NP) provided saliva and clinical parameters of periodontal health were recorded. Salivary concentrations of interleukin (IL)\u20101\u03b2, IL\u20106, matrix metalloproteinase\u20108 (MMP\u20108), macrophage inflammatory protein\u20101\u03b1 (MIP\u20101\u03b1), adiponectin and resistin were measured by immunoassay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Salivary analyte concentrations for IL\u20101\u03b2, MMP\u20108 and resistin correlated with clinical parameters of periodontitis, with MMP\u20108 demonstrating the strongest positive correlation with PD \u22655\u00a0mm (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.0001). Periodontal health was reflected in salivary analyte concentrations by group, with concentrations of IL\u20101\u03b2 and MMP\u20108 showing significant associations with periodontitis (<jats:italic>p<\/jats:italic>\u00a0\u2264\u00a00.04) that increased in concentration from health to DWoP to DWP. Odds ratio (OR) analyses showed that MMP\u20108 discriminated periodontitis from NP (OR of 8.12; 95% CI: 1.01\u201365.33; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03) and in the presence of T2DM (DWP vs DWoP, OR\u00a0=\u00a05.09; 95% CI: 1.24\u201320.92; <jats:italic>p<\/jats:italic>\u00a0=\u00a00.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Salivary MMP\u20108 and IL\u20101\u03b2 discriminate periodontitis in T2DM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13393","type":"journal-article","created":{"date-parts":[[2020,10,24]],"date-time":"2020-10-24T03:58:34Z","timestamp":1603511914000},"page":"216-225","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["Salivary biomarkers for discriminating periodontitis in the presence of diabetes"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7657-4604","authenticated-orcid":false,"given":"Craig S.","family":"Miller","sequence":"first","affiliation":[{"name":"Department of Oral Health Practice Center for Oral Health Research College of Dentistry University of Kentucky  Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Public Health Western Kentucky University  Bowling Green KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"III","given":"Dolph R.","family":"Dawson","sequence":"additional","affiliation":[{"name":"Department of Oral Health Practice Center for Oral Health Research College of Dentistry University of Kentucky  Lexington KY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9743-6585","authenticated-orcid":false,"given":"Jeffrey L.","family":"Ebersole","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Nevada  Las Vegas NV USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,17]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"160","article-title":"Reduction of melatonin level in patients with type II diabetes and periodontal diseases","volume":"8","author":"Abdolsamadi H.","year":"2014","journal-title":"Journal of Dental Research, Dental Clinics, Dental Prospects"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-3930.62595"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/7891323"},{"key":"e_1_2_9_5_1","volume-title":"Diagnosis","author":"American Diabetes Association","year":"2020"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0906-6713.2002.003422.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-019-0510-2"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2018.1468922"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijdr.IJDR_167_14"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0105181"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/154405910808700707"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S230060"},{"key":"e_1_2_9_14_1","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4103\/jisp.jisp_512_19","article-title":"Biomarkers in biological fluids in adults with periodontitis and\/or obesity: A meta\u2010analysis","volume":"24","author":"Brum R. 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