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Randomized controlled trials (RCTs) and non\u2010randomized controlled studies (NRSs) comparing IIP with CTG and without CTG over a mean follow\u2010up of at least 12\u00a0months were included for a qualitative analysis. Meta\u2010analyses were performed on data provided by RCTs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 1814 records, 5 RCTs and 3 NRSs reported on 409 (IIP + CTG: 246, IIP: 163) immediately installed implants with a mean follow\u2010up ranging from 12 to 108\u00a0months. Only 1 RCT showed low risk of bias. Meta\u2010analysis revealed a significant difference in terms of vertical mid\u2010facial soft tissue change between IIP + CTG and IIP pointing to 0.41\u00a0mm (95% CI [0.21; 0.61], <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.001) in favour of soft tissue grafting. This outcome was clinically relevant since the risk for \u22651\u00a0mm asymmetry in mid\u2010facial vertical soft tissue level was 12 times (RR 12.10, 95% CI [2.57; 56.91], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.002) lower following IIP + CTG. Soft tissue grafting also resulted in a trend towards less bleeding on probing (MD 17%, 95% CI [\u221235%; 1%], <jats:italic>p<\/jats:italic>\u00a0=\u00a0.06). Meta\u2010analyses did not reveal significant differences in terms of pink aesthetic score, marginal bone level change and probing depth. Results were inconclusive for horizontal mid\u2010facial soft tissue change and papilla height change. Based on GRADE guidelines, a moderate recommendation for the use of a CTG following IIP can be made.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CTG contributes to mid\u2010facial soft tissue stability following IIP. Therefore, CTG should be considered when elevated risk for mid\u2010facial recession is expected in the aesthetic zone (thin gingival biotype, &lt;0.5\u00a0mm buccal bone thickness).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13397","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T19:49:12Z","timestamp":1604087352000},"page":"284-301","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":112,"title":["Immediate implant placement with or without connective tissue graft: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1547-057X","authenticated-orcid":false,"given":"Lorenz","family":"Seyssens","sequence":"first","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Oral Health Sciences Department of Periodontology and Oral Implantology Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liesa","family":"De Lat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Oral Health Sciences Department of Periodontology and Oral Implantology Ghent University Ghent Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5042-2875","authenticated-orcid":false,"given":"Jan","family":"Cosyn","sequence":"additional","affiliation":[{"name":"Faculty of Medicine and Health Sciences, Oral Health Sciences Department of Periodontology and Oral Implantology Ghent University Ghent Belgium"},{"name":"Faculty of Medicine and Pharmacy Oral Health Research Group (ORHE) Vrije Universiteit Brussel (VUB) Brussels Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,11,20]]},"reference":[{"key":"e_1_2_9_1_2_1","volume-title":"Practical statistics for medical research","author":"Altman D. 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