{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T18:11:07Z","timestamp":1783015867674,"version":"3.54.6"},"reference-count":29,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,16]],"date-time":"2020-12-16T00:00:00Z","timestamp":1608076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the local immunoinflammatory profiles in localized aggressive periodontitis patients (LAP) before and after periodontal treatment and maintenance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty\u2010six African\u2010Americans with LAP (7\u201321\u00a0years old) were included. After periodontal examination, all patients received periodontal treatment with mechanical debridement plus systemic amoxicillin\/metronidazole for 7\u00a0days. Gingival crevicular fluid was collected from diseased and healthy sites at baseline and 3, 6, 12, and 24\u00a0months following treatment. Levels of 16 inflammatory\/bone resorption markers were determined using Milliplex<jats:sup>\u00ae<\/jats:sup>. Univariate and correlation analyses were performed among all parameters\/biomarkers. Discriminant analyses (DA) evaluated profile differences between LAP diseased and healthy sites at each time point as compared to the baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reductions in the clinical parameters (except for visible plaque) were observed at all time points compared to the baseline. Levels of IL\u201012p70, IL\u20102, IL\u20106, MIP\u20101\u03b1, RANKL, and OPG were reduced after treatment, and several cytokines\/chemokines were correlated with clinical parameters reductions. DA showed that differences in the immunoinflammatory profiles between LAP diseased and healthy sites decreased after periodontal treatment compared to the baseline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Periodontal treatment modified the local immunoinflammatory profile of LAP sites in the long term, as suggested by changes in biomarkers from baseline, along with clinical stability of the disease. (Clinicaltrials.gov number, NCT01330719).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13404","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T11:48:39Z","timestamp":1605700119000},"page":"237-248","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Treatment of localized aggressive periodontitis alters local host immunoinflammatory profiles: A long\u2010term evaluation"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6928-8522","authenticated-orcid":false,"given":"Luciana S.","family":"Branco\u2010de\u2010Almeida","sequence":"first","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida  Gainesville Florida USA"},{"name":"Post Graduate Program in Dentistry School of Dentistry Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0065-0236","authenticated-orcid":false,"given":"Yenisel","family":"Cruz\u2010Almeida","sequence":"additional","affiliation":[{"name":"Pain Research &amp; Intervention Center of Excellence University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yandy","family":"Gonzalez\u2010Marrero","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0882-017X","authenticated-orcid":false,"given":"Rachad","family":"Kudsi","sequence":"additional","affiliation":[{"name":"Division of Periodontology College of Dentistry University of Kentucky  Lexington Kentucky USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8027-3372","authenticated-orcid":false,"given":"Izabel C. V.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Post Graduate Program in Dentistry School of Dentistry Federal University of Maranh\u00e3o  S\u00e3o Lu\u00eds Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Dolia","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7127-3693","authenticated-orcid":false,"given":"Ikramuddin","family":"Aukhil","sequence":"additional","affiliation":[{"name":"Department of Periodontology College of Dentistry University of Florida  Gainesville Florida 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