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After 8\u00a0weeks of plaque accumulation, the 16 chronic defects were randomly treated with either CAF alone or CAF and HA\u2010gel (CAF\/HA). Clinical and histological outcomes were evaluated at 10\u00a0weeks post\u2010surgically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to baseline, the clinical measurements at 10\u00a0weeks revealed a statistically significant decrease in gingival recession for both CAF (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) and CAF\/HA (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) groups. Statistically significant differences were found in clinical attachment level (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05) and width of gingival recession (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.01) favouring the CAF\/HA group. Bone formation was statistically significantly greater in the CAF\/HA group than in the CAF group (1.84\u00a0\u00b1\u00a01.16\u00a0mm vs., 0.72\u00a0\u00b1\u00a00.62\u00a0mm, respectively, <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05). Formation of cementum and connective tissue attachment were statistically significantly higher in the CAF\/HA group compared with the CAF group (i.e. 4.31\u00a0\u00b1\u00a01.78\u00a0mm versus 2.40\u00a0\u00b1\u00a01.35\u00a0mm and 1.69\u00a0\u00b1\u00a00.98\u00a0mm versus 0.74\u00a0\u00b1\u00a00.68\u00a0mm, respectively (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.05)).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present data have for the first time provided histologic evidence for periodontal regeneration of gingival recession defects following treatment with CAF and HA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical relevance<\/jats:title><jats:p>The use of HA in conjunction with CAF may represent a novel modality for treating gingival recession defects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13433","type":"journal-article","created":{"date-parts":[[2021,1,29]],"date-time":"2021-01-29T19:25:59Z","timestamp":1611948359000},"page":"570-580","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Healing of buccal gingival recessions following treatment with coronally advanced flap alone or combined with a cross\u2010linked hyaluronic acid gel. An experimental study in dogs"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0663-0524","authenticated-orcid":false,"given":"Yoshinori","family":"Shirakata","sequence":"first","affiliation":[{"name":"Department of Periodontology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2675-484X","authenticated-orcid":false,"given":"Toshiaki","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Periodontology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Kawakami","sequence":"additional","affiliation":[{"name":"Department of Periodontology Kagoshima University Graduate School of Medical and Dental Sciences Kagoshima 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