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L\u2010PRF, A\u2010PRF+ or control was randomly assigned, leaving one empty socket\/edentulous site between conditions. CBCT scans were obtained immediately after tooth extraction and after 3\u00a0months of healing. Horizontal and vertical dimensional changes of the ridge and socket fill were calculated. Histological and micro\u2010CT analysis of bone biopsies were used to evaluate post\u2010surgical bone structural healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean horizontal and vertical changes at 1\u2010mm below the crest (buccal and palatal side) were similar for the three sites (<jats:italic>p\u00a0<\/jats:italic>&gt;\u00a00.05). For the socket fill, L\u2010PRF (85.2%) and A\u2010PRF+ (83.8%) showed superior values than the control (67.9%). The histological and radiological analysis reported more newly formed bone for the PRF groups, without any significant differences between both.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>PRF matrices failed to reduce the dimensional changes after multiple tooth extractions in the premaxilla. After 3\u2010month healing, both PRF matrices showed radiographically a significant superiority for the socket fill. Histologically, they seemed to accelerate new bone formation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13463","type":"journal-article","created":{"date-parts":[[2021,4,13]],"date-time":"2021-04-13T04:20:42Z","timestamp":1618287642000},"page":"984-995","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Effect of different platelet\u2010rich fibrin matrices for ridge preservation in multiple tooth extractions: A split\u2010mouth randomized controlled clinical trial"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5329-3113","authenticated-orcid":false,"given":"Ana B.","family":"Castro","sequence":"first","affiliation":[{"name":"Department of Oral Health Sciences Section of Periodontology and Oral Microbiology KU Leuven University Hospitals Leuven Dentistry Leuven 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