{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,31]],"date-time":"2025-12-31T20:12:58Z","timestamp":1767211978338,"version":"3.40.5"},"reference-count":22,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T00:00:00Z","timestamp":1621209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the efficacy of a commercially available adjunctive phototherapy protocol (\u201cPerio\u20101\u201d) in treatment of periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In an examiner\u2010blind, randomized, controlled, split\u2010mouth, multicentre study, 60 periodontitis patients received root surface debridement (RSD) in sextants either alone (control sextants) or with the adjunctive phototherapy protocol (test sextants). Re\u2010evaluation was performed at 6, 12 and 24\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No statistically significant differences in mean (\u00b1 standard deviation) clinical attachment level (CAL) change from baseline to week 24 were observed between test (\u22121.00\u00a0\u00b1\u00a01.16\u00a0mm) and control sextants (\u22120.87\u00a0\u00b1\u00a00.79\u00a0mm) at sites with probing pocket depths (PPDs) \u22655\u00a0mm (\u201cdeep sites\u201d) at baseline (<jats:italic>p\u00a0=\u00a0<\/jats:italic>.212). Comparisons between test and control sextants for all other parameters (CAL change at all sites, PPD change at deep sites\/all sites, bleeding on probing, plaque scores), and for all change intervals, failed to identify any statistically significant differences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The phototherapy protocol did not provide any additional clinical benefits over those achieved by RSD alone. (German Clinical Trials Register DRKS00011229).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13465","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T02:55:10Z","timestamp":1617591310000},"page":"1093-1102","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["No benefit of an adjunctive phototherapy protocol in treatment of periodontitis: A split\u2010mouth randomized controlled trial"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7153-4865","authenticated-orcid":false,"given":"Philip M.","family":"Preshaw","sequence":"first","affiliation":[{"name":"School of Dental Sciences Newcastle University  Newcastle upon Tyne UK"},{"name":"School of Dentistry University of Dundee  Dundee UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark","family":"Ide","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Oral and Craniofacial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan M.","family":"Bissett","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9072-8083","authenticated-orcid":false,"given":"Richard","family":"Holliday","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nichola","family":"Lansdowne","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kimberley","family":"Pickering","sequence":"additional","affiliation":[{"name":"School of Dental Sciences Newcastle University  Newcastle upon Tyne UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judy A.","family":"Taylor","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Oral and Craniofacial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana M.","family":"Levonian","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Oral and Craniofacial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Pleasance","sequence":"additional","affiliation":[{"name":"Faculty of Dentistry Oral and Craniofacial Sciences King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Elena","family":"Guarnelli","sequence":"additional","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010implant Diseases University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Simonelli","sequence":"additional","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010implant Diseases University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Fabbri","sequence":"additional","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010implant Diseases University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4621-7809","authenticated-orcid":false,"given":"Roberto","family":"Farina","sequence":"additional","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010implant Diseases University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fotinos S.","family":"Panagakos","sequence":"additional","affiliation":[{"name":"West Virginia University School of Dentistry  Morgantown WV USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Trombelli","sequence":"additional","affiliation":[{"name":"Research Centre for the Study of Periodontal and Peri\u2010implant Diseases University of Ferrara  Ferrara Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,5,17]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/ijd.13349"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170172"},{"key":"e_1_2_11_5_1","first-page":"1","article-title":"Response to LETTER \u201cLaser parameters in systematic reviews\u201d by Dr. Carla DAMANTE","author":"Chapple I. 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