{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T18:28:46Z","timestamp":1778783326922,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,5,6]],"date-time":"2021-05-06T00:00:00Z","timestamp":1620259200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To report the 36\u2010month follow\u2010up of a trial comparing the adjunct of a xenogenic collagen matrix (CMX) or connective tissue graft (CTG) to coronally advanced flaps (CAF) for coverage of multiple adjacent recessions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Material and methods<\/jats:title><jats:p>125 subjects (61 CMX) with 307 recessions in 8 centres from the parent trial were followed\u2010up for 36\u00a0months. Primary outcome was change in position of the gingival margin. Multilevel analysis used centre, subject and tooth as levels and baseline parameters as covariates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No differences were observed between the randomized and the follow\u2010up population. Average baseline recession was 2.6\u00a0\u00b1\u00a01.0\u00a0mm. 3\u2010year root coverage was 1.5\u00a0\u00b1\u00a01.5\u00a0mm for CMX and 2.0\u00a0\u00b1\u00a01.0\u00a0mm for CTG (difference of 0.32\u00a0mm, 95% CI from \u22120.02 to 0.65\u00a0mm). The upper limit of the confidence interval was over the non\u2010inferiority margin of 0.25\u00a0mm. No treatment differences in position of the gingival margin were observed between 6\u2010 and 36\u2010month follow\u2010up (difference 0.06\u00a0mm, 95% CI \u22120.17 to 0.29\u00a0mm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CMX was not non\u2010inferior with respect to CTG in multiple adjacent recessions. No differences in stability of root coverage were observed between groups and in changes from 6 to 36\u00a0months. Previously reported shorter time to recovery, lower morbidity and more natural appearance of tissue texture and contour observed for CMX in this trial are also relevant in clinical decision\u2010making.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13466","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T02:57:05Z","timestamp":1617591425000},"page":"962-969","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Autologous connective tissue graft or xenogenic collagen matrix with coronally advanced flaps for coverage of multiple adjacent gingival recession. 36\u2010month follow\u2010up of a randomized multicentre trial"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2743-0137","authenticated-orcid":false,"given":"Maurizio S.","family":"Tonetti","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Implantology Shanghai Key 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