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Mean effects (ME) and 95% confidence intervals (CIs) were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six studies with high risk of bias were included.<\/jats:p><jats:p>PICO#1: In 26 patients without periodontitis and in 69 treated periodontitis patients, minimal changes in periodontal outcomes were reported after orthodontic therapy (<jats:italic>p\u00a0<\/jats:italic>&gt;\u00a00.05). A significant CAL gain (mm) (ME\u00a0=\u00a03.523; 95% CI [2.353; 4.693]; <jats:italic>p<\/jats:italic>\u00a0&lt;\u00a00.001) was observed in 214 patients when periodontal outcomes were retrieved before a combined periodontal and orthodontic therapy.<\/jats:p><jats:p>PICO#2: Orthodontic variables were scarcely reported, and objective assessment of the results on orthodontic therapy was missing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Based on a small number of low\u2010quality studies, in non\u2010periodontitis and in stable treated periodontitis patients, OTM had no significant impact on periodontal outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13487","type":"journal-article","created":{"date-parts":[[2021,5,17]],"date-time":"2021-05-17T06:59:10Z","timestamp":1621234750000},"page":"72-101","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":86,"title":["Effect of orthodontic therapy in periodontitis and non\u2010periodontitis patients: a systematic review with meta\u2010analysis"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3997-6900","authenticated-orcid":false,"given":"Conchita","family":"Martin","sequence":"first","affiliation":[{"name":"Section of Orthodontics Department of Dental Clinical Specialties Complutense University of Madrid Madrid Spain"},{"name":"BIOCRAN (Craniofacial Biology: Orthodontics and Dentofacial Orthopedics) Research Group Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Celis","sequence":"additional","affiliation":[{"name":"Section of Orthodontics Department of Dental Clinical Specialties Complutense University of Madrid Madrid Spain"},{"name":"Department of Dental Clinical Specialties Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9837-5393","authenticated-orcid":false,"given":"Nagore","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"Section of Periodontics Department of Dental Clinical Specialties Complutense University of Madrid Madrid Spain"},{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010implant Diseases) Research Group Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Bollain","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties Complutense University of Madrid Madrid Spain"},{"name":"Section of Periodontics Department of Dental Clinical Specialties Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8254-5471","authenticated-orcid":false,"given":"Georgios N.","family":"Antonoglou","sequence":"additional","affiliation":[{"name":"Section of Periodontics Department of Dental Clinical Specialties Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-1416","authenticated-orcid":false,"given":"Elena","family":"Figuero","sequence":"additional","affiliation":[{"name":"Section of Periodontics Department of Dental Clinical Specialties Complutense University of Madrid Madrid Spain"},{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010implant Diseases) Research Group Complutense University of Madrid Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.11607\/prd.4523"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajodo.2019.10.010"},{"issue":"2","key":"e_1_2_10_4_1","first-page":"63","article-title":"Evaluation of Adjunctive Use of Low\u2010Level Diode Laser Biostimulation with Combined Orthodontic Regenerative Therapy","volume":"21","author":"Attia M. 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