{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T15:29:58Z","timestamp":1792337398239,"version":"4.4.0"},"reference-count":43,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,6]],"date-time":"2021-09-06T00:00:00Z","timestamp":1630886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002739","name":"Aarhus Universitets Forskningsfond","doi-asserted-by":"publisher","award":["AUFF\u2010E 2019\u20107\u20103"],"award-info":[{"award-number":["AUFF\u2010E 2019\u20107\u20103"]}],"id":[{"id":"10.13039\/501100002739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate whether halitosis is associated with impaired oral\u2010health\u2010related quality of life (OHRQoL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This is a systematic review of the literature. Electronic searches were performed in PubMed via Medline, Web of Science, Scopus, and EMBASE up to and including June 2021. Observational studies that assessed halitosis in association with OHRQoL were included. The pooled standardized mean difference (SMD) was estimated by meta\u2010analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Thirteen studies were included in the review; however, the meta\u2010analysis included only 10 studies, all cross\u2010sectional, comprising 2692 individuals. The overall meta\u2010analysis showed an association between halitosis and impaired OHRQoL (SMD 0.51; 95% confidence interval 0.27\u20130.75). Subgroup analyses, however, indicated that this association remained only among adults. Neither the OHRQoL instrument nor the halitosis assessment method, or the cultural background, influenced the pooled estimates. Meta\u2010regression analyses revealed that the OHRQoL instrument, the halitosis assessment method, and the sample composition did not explain the between\u2010study heterogeneity. Methodological quality appeared to explain 20% of the overall heterogeneity, as studies with high risk of bias overestimated the magnitude of the association.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings suggest that halitosis is associated with impaired OHRQoL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.13530","type":"journal-article","created":{"date-parts":[[2021,8,18]],"date-time":"2021-08-18T21:24:29Z","timestamp":1629321869000},"page":"1458-1469","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The association between halitosis and oral\u2010health\u2010related quality of life: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2976-1386","authenticated-orcid":false,"given":"Luisa","family":"Schertel Cassiano","sequence":"first","affiliation":[{"name":"Section for Periodontology, Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhiya","family":"Abdullahi","sequence":"additional","affiliation":[{"name":"Section for Periodontology, Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1bio R. M.","family":"Leite","sequence":"additional","affiliation":[{"name":"Section for Periodontology, Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6170-507X","authenticated-orcid":false,"given":"Rodrigo","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Section for Periodontology, Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.","family":"Peres","sequence":"additional","affiliation":[{"name":"National Dental Research Institute Singapore National Dental Centre  Singapore"},{"name":"Oral Health Academic Clinical Programme, Health Services and Systems Research Programme Duke\u2010NUS Medical School  Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4288-6300","authenticated-orcid":false,"given":"Gustavo G.","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Section for Periodontology, Department of Dentistry and Oral Health Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4034\/PBOCI.2019.191.14"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2005.01099.x"},{"key":"e_1_2_11_4_1","first-page":"28","volume-title":"Statistics with confidence","author":"Altman D. 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