{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:37:21Z","timestamp":1790919441186,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T00:00:00Z","timestamp":1633305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008439","name":"Electro Medical Systems","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008439","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the clinical efficacy of full\u2010mouth scaling (FMS), full\u2010mouth disinfection (FMD), and FMD with adjuvant erythritol air\u2010polishing (FMDAP) compared to quadrant\u2010wise debridement (Q\u2010SRP) in patients with periodontitis stage III\/IV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this four\u2010arm parallel, prospective, randomized, controlled multi\u2010centre study, changes of pocket probing depths (PPDs), clinical attachment level (CAL), bleeding on probing (BOP), and proportion of closed pockets (PPD \u22644\u2009mm without BOP) were evaluated at baseline and after 3 and 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From 190 randomly participating patients, 172 were included in the final analysis. All groups showed significant (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) improvements in all clinical parameters over 3 and 6\u00a0months. During the study period, FMDAP showed significantly higher reductions of mean PPD in teeth with moderate (PPD 4\u20136\u2009mm) and deep (PPD\u2009&gt;\u20096\u2009mm) pockets and significantly increased proportions of pocket closure than Q\u2010SRP. Patients treated with FMD had significantly greater PPD reduction in deep pockets and a higher percentage of pocket closure after 3 months but not after 6\u00a0months compared to Q\u2010SRP. CAL and BOP changes did not significantly differ among all groups. Efficiency of treatment (time effort to gain one closed pocket) was significantly higher for FMDAP, FMD, and FMS compared to Q\u2010SRP (6.3, 8.5, 9.5 vs. 17.8\u00a0min per closed pocket; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>All treatment modalities were effective, without significant differences between full\u2010mouth approaches. FMDAP showed improved clinical outcomes over Q\u2010SRP for moderate and deep pockets after 6\u00a0months. Full\u2010mouth protocols were more time\u2010efficient than conventional Q\u2010SRP.<\/jats:p><\/jats:sec><jats:sec><jats:title>Clinical Significance<\/jats:title><jats:p>The trial was registered in a clinical trial database (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>: NCT03509233).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13548","type":"journal-article","created":{"date-parts":[[2021,9,13]],"date-time":"2021-09-13T23:44:40Z","timestamp":1631576680000},"page":"1516-1527","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Comparison of three full\u2010mouth concepts for the non\u2010surgical treatment of stage <scp>III<\/scp> and <scp>IV<\/scp> periodontitis: A randomized controlled trial"],"prefix":"10.1111","volume":"48","author":[{"given":"Jamal M.","family":"Stein","sequence":"first","affiliation":[{"name":"Department of Operative Dentistry, Periodontology and Preventive Dentistry University Hospital (RWTH)  Aachen Germany"},{"name":"Private Practice  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sareh Said","family":"Yekta\u2010Michael","sequence":"additional","affiliation":[{"name":"Department of Orthodontics University Hospital (RWTH)  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florian","family":"Schittenhelm","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry, Periodontology and Preventive Dentistry University Hospital (RWTH)  Aachen Germany"},{"name":"Private Practice  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Reichert","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Periodontology Martin Luther University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Kupietz","sequence":"additional","affiliation":[{"name":"Department of Operative Dentistry and Periodontology Martin Luther University  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Dommisch","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine and Oral Surgery Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin  Berlin Germany"},{"name":"Berlin Institute of Health  Berlin Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian","family":"Kasaj","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Operative Dentistry University Medical Center  Mainz Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Wied","sequence":"additional","affiliation":[{"name":"Department of Medical Statistics University Hospital (RWTH)  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Octavia\u2010Carolina","family":"Vela","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Anton Sculean Center for Research and Peri\u2010Implant Diseases Victor Babes University of Medicine and Pharmacy  Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan\u2010Ioan","family":"Stratul","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Anton Sculean Center for Research and Peri\u2010Implant Diseases Victor Babes University of Medicine and Pharmacy  Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,4]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2010.100468"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6979.2004.00461.x"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1996.tb00519.x"},{"key":"e_1_2_10_5_1","first-page":"e1","article-title":"Consensus conference findings on supragingival and subgingival air\u2010polishing","volume":"38","author":"Cobb C. 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