{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T20:05:00Z","timestamp":1789416300140,"version":"build-2803163510"},"reference-count":43,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T00:00:00Z","timestamp":1633478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the associations between metabolic risk factors and periodontitis in young adults.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>The study included 1123 participants, aged 19\u201340\u2009years, in Taiwan. Metabolic syndrome components were defined by the International Diabetes Federation criteria. Localized periodontitis was graded to healthy (<jats:italic>n<\/jats:italic>\u00a0=\u2009828) and stage II\/III (<jats:italic>n<\/jats:italic>\u00a0=\u2009295) according to the 2017 criteria of the World Workshop. Multiple logistic regression analysis with adjustment for sex, age, betel nut consumption, and smoking were used to determine the associations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Greater waist circumference, serum triglycerides, and serum uric acid were associated with higher localized stage II\/III periodontitis risk [odds ratio (OR) and 95% confidence interval (CI): 1.04 (1.02\u20131.05), 1.004 (1.002\u20131.006), and 1.10 (1.00\u20131.21), respectively]. There were no associations for total cholesterol, high\u2010density lipoprotein, and blood pressure. There was a non\u2010linear association between fasting glucose and localized stage II\/III periodontitis, where the turning point was 105\u2009mg\/dl [OR: 0.97 (0.95\u20130.99) and 1.06 (1.00\u20131.13) when the levels were\u2009&lt;105 and\u2009\u2265105\u2009mg\/dl, respectively].<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risks of localized stage II\/III periodontitis vary with metabolic components, in which waist circumference, serum triglycerides, and serum uric acid are the risk factors, whereas plasma glucose shows a non\u2010linear relationship in young adults.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13555","type":"journal-article","created":{"date-parts":[[2021,10,4]],"date-time":"2021-10-04T21:28:21Z","timestamp":1633382901000},"page":"1549-1558","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Associations between metabolic biomarkers and localized stage <scp>II<\/scp>\/<scp>III<\/scp> periodontitis in young adults: The <scp>CHIEF<\/scp> Oral Health study"],"prefix":"10.1111","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-1545","authenticated-orcid":false,"given":"Kun\u2010Zhe","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Medicine Hualien Armed Forces General Hospital  Hualien Taiwan"},{"name":"Department of Dentistry Tri\u2010Service General Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Dental Science National Defense Medical Center  Taipei Taiwan"},{"name":"School of Dentistry National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5103-7431","authenticated-orcid":false,"given":"Fang\u2010Ying","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Medical Research National Taiwan University Hospital Hsin\u2010Chu Branch  Hsin\u2010Chu 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