{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T17:05:41Z","timestamp":1792515941769,"version":"4.5.0"},"reference-count":36,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,10,5]],"date-time":"2021-10-05T00:00:00Z","timestamp":1633392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100019000","name":"Medical Affairs Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019000","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To clarify the association between systemic and hepatic inflammation and localized periodontitis which has been reported to vary among races.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The study included 1112 military males, aged 18\u201340 years, in Taiwan. Participants were classified as periodontally healthy\/stage I (<jats:italic>n<\/jats:italic> = 796) or stage II\/III periodontitis (<jats:italic>n<\/jats:italic> = 316), according to the 2017 world workshop criteria. Systemic and hepatic inflammation were defined by the highest tertiles of blood leukocyte counts (7.51 \u00d7 10<jats:sup>3<\/jats:sup>\/\u03bcl) and alanine aminotransferase (30 U\/L), respectively. Multiple logistic regression analysis with adjustments for age, metabolic syndrome, betel nut consumption and smoking was carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a significant association between high systemic inflammation, irrespective of hepatic inflammation severity, and localized stage II\/III periodontitis (odds ratio [OR], 1.62 [1.09\u20132.42] and 1.47 [1.00\u20132.15], respectively, in the presence of high or no hepatic inflammation. However, no significant association was found among participants with low systemic inflammation, irrespective of the severity of hepatic inflammation (OR, 1.31 [0.91\u20131.91]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An association between hepatic inflammation and localized periodontitis in Taiwanese was observed only if systemic inflammation coexisted, possibly accounting for the reported differences in the association between Japanese and non\u2010Asian populations in prior studies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13556","type":"journal-article","created":{"date-parts":[[2021,10,8]],"date-time":"2021-10-08T05:06:54Z","timestamp":1633669614000},"page":"458-466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Association of hepatic and systemic inflammation with localized stage <scp>II<\/scp>\/<scp>III<\/scp> periodontitis in young males: The <scp>CHIEF<\/scp> oral health study"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-1545","authenticated-orcid":false,"given":"Kun\u2010Zhe","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Medicine Hualien Armed Forces General Hospital  Hualien Taiwan"},{"name":"Department of Dentistry Tri\u2010Service General Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Dental Science National Defense Medical Center  Taipei Taiwan"},{"name":"School of Dentistry National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5103-7431","authenticated-orcid":false,"given":"Fang\u2010Ying","family":"Su","sequence":"additional","affiliation":[{"name":"Institute of Statistics National Chiao Tung University  Hsinchu City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7251-3361","authenticated-orcid":false,"given":"Wan\u2010Chien","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Dentistry Tri\u2010Service General Hospital  Taipei Taiwan"},{"name":"Graduate Institute of Dental Science National Defense Medical Center  Taipei Taiwan"},{"name":"School of Dentistry National Defense Medical Center  Taipei Taiwan"},{"name":"Biotechnology R&amp;D Center National Taiwan University Hospital Hsinchu Branch  Hsinchu County Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5859-8429","authenticated-orcid":false,"given":"Yen\u2010Po","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine Taipei Tzu\u2010Chi Hospital  New Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5509-1056","authenticated-orcid":false,"given":"Gen\u2010Min","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Medicine Hualien Armed Forces General Hospital  Hualien Taiwan"},{"name":"Department of Internal Medicine Tri\u2010Service General Hospital, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,10,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.2334\/josnusd.57.335"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0579"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67402-8"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph15030545"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v23.i25.4587"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0628"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63147-9"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2007.04952.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.00234"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016350903291913"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034513507956"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12313"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472-6831-14-133"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2013.07.012"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12758"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/odi.12601"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.4330\/wjc.v8.i8.464"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530319666181129163802"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.8951"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12534"},{"issue":"1","key":"e_1_2_12_22_1","first-page":"38","article-title":"Utility of analytical parameters in the diagnosis of liver disease","volume":"24","author":"Moreno Borque A.","year":"2007","journal-title":"Anales de Medicina Interna"},{"key":"e_1_2_12_23_1","first-page":"219","article-title":"Aspartate aminotransferase\u2013key enzyme in the human systemic metabolism","volume":"70","author":"Otto\u2010Slusarczyk D.","year":"2016","journal-title":"Post\u0229py Higieny i Medycyny Do\u015bwiadczalnej (Online)"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2125.2007.03001.x"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-137-1-200207020-00006"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2010.01671.x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0757.1997.tb00195.x"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00535-016-1264-3"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.18-0006"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0275"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-47625-3"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1136\/jramc-2017-000899"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2298"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12861"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3901402"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2010.00748.x"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2007.060216"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13556","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpe.13556","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13556","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T18:26:46Z","timestamp":1692988006000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.13556"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,5]]},"references-count":36,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/jcpe.13556"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.13556","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,5]]},"assertion":[{"value":"2021-08-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}