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The replication cohort included 1124 individuals, 65\u201398\u2009years old (67% female, 45% Hispanic, 30% Black, 23% White) with available genome\u2010wide genotypes and full\u2010mouth periodontal status. Microbial profiles using checkerboard DNA\u2013DNA hybridization and 16SrRNA sequencing were available from 912 and 739 participants, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Using gene\u2010specific <jats:italic>p<\/jats:italic>\u2010values after linkage disequilibrium pruning, the following gene\/phenotype associations replicated successfully: <jats:italic>CLEC19A<\/jats:italic> with edentulism and %teeth with pocket depth (PD) \u22654\u2009mm; <jats:italic>IL37<\/jats:italic>, <jats:italic>HPVC1<\/jats:italic>, <jats:italic>TRPS1<\/jats:italic>, <jats:italic>ABHD12B<\/jats:italic>, <jats:italic>LDLRAD4 (C180rF1)<\/jats:italic>, <jats:italic>TGM3<\/jats:italic>, and <jats:italic>GRK5<\/jats:italic> with %teeth with PD \u22654\u2009mm; <jats:italic>DAB2IP<\/jats:italic> with presence of PD \u22656\u2009mm; <jats:italic>KIAA1715<\/jats:italic>(<jats:italic>LNPK<\/jats:italic>), <jats:italic>ROBO2<\/jats:italic>, <jats:italic>RAB28<\/jats:italic>, <jats:italic>LINC01017<\/jats:italic>, <jats:italic>NELL1<\/jats:italic>, <jats:italic>LDLRAD4<\/jats:italic>(<jats:italic>C18orF1<\/jats:italic>), and <jats:italic>CRYBB2P1<\/jats:italic> with %teeth with clinical attachment level (CAL) \u22653\u2009mm; <jats:italic>RUNX2<\/jats:italic> and <jats:italic>LAMA2<\/jats:italic> with %teeth with CAL \u22655\u2009mm; and <jats:italic>KIAA1715<\/jats:italic>(<jats:italic>LNPK<\/jats:italic>) with high colonization by <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>. In addition, <jats:italic>CLEC19A<\/jats:italic>, <jats:italic>IQSEC1<\/jats:italic>, and <jats:italic>EMR1<\/jats:italic> associated with microbial abundance based on checkerboard data, <jats:italic>LBP<\/jats:italic> and <jats:italic>NCR2<\/jats:italic> with abundance based on sequencing data, and <jats:italic>NCR2<\/jats:italic> with microbial diversity based on sequencing data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Several gene loci identified in published GWAS as associated with periodontitis\u2010related phenotypes replicated successfully in an elderly cohort.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13605","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T12:35:57Z","timestamp":1645187757000},"page":"414-427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Replication of gene polymorphisms associated with periodontitis\u2010related 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