{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T03:27:54Z","timestamp":1774063674214,"version":"3.50.1"},"reference-count":40,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,4]],"date-time":"2022-07-04T00:00:00Z","timestamp":1656892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study the role of sclerostin in periodontal ligament (PDL) as a homeostatic regulator in biophysical\u2010force\u2010induced tooth movement (BFTM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>BFTM was performed in rats, followed by microarray, immunofluorescence, in situ hybridization, and real\u2010time polymerase chain reaction for the detection and identification of the molecules. The periodontal space was analysed via micro\u2010computed tomography. Effects on osteoclastogenesis and bone resorption were evaluated in the bone\u2010marrow\u2010derived cells in mice. In vitro human PDL cells were subjected to biophysical forces.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the absence of BFTM, sclerostin was hardly detected in the periodontium except in the PDL and alveolar bone in the furcation region and apex of the molar roots. However, sclerostin was up\u2010regulated in the PDL in vivo by adaptable force, which induced typical transfiguration without changes in periodontal space as well as in vitro PDL cells under compression and tension. In contrast, the sclerostin level was unaffected by heavy force, which caused severe degeneration of the PDL and narrowed periodontal space. Sclerostin inhibited osteoclastogenesis and bone resorption, which corroborates the accelerated tooth movement by the heavy force.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Sclerostin in PDL may be a key homeostatic molecule in the periodontium and a biological target for the therapeutic modulation of BFTM.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13624","type":"journal-article","created":{"date-parts":[[2022,4,4]],"date-time":"2022-04-04T02:00:33Z","timestamp":1649037633000},"page":"932-944","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sclerostin in periodontal ligament: Homeostatic regulator in biophysical force\u2010induced tooth movement"],"prefix":"10.1111","volume":"49","author":[{"given":"Yoo\u2010Sung","family":"Nam","sequence":"first","affiliation":[{"name":"Dental Science Research Institute, School of Dentistry Chonnam National University  Gwangju South 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