{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:48:04Z","timestamp":1792514884178,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,21]],"date-time":"2022-08-21T00:00:00Z","timestamp":1661040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["2369\/18"],"award-info":[{"award-number":["2369\/18"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aetiology and pathogenesis of peri\u2010implantitis are currently under active research. This study aimed to dissect the pathogenesis of murine experimental peri\u2010implantitis and assess Resolvin D2 (RvD2) as a new treatment modality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Four weeks following titanium implant insertion, mice were infected with <jats:italic>Porphyromonas gingivalis<\/jats:italic> using single or multiple oral lavages. RvD2 was administrated following infection, and tissues were analysed using flow cytometry, quantitative RT\u2010PCR, taxonomic profiling, and micro\u2010computed tomography.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Repeated infections with <jats:italic>Pg<\/jats:italic> resulted in microbial dysbiosis and a higher influx of innate and adaptive leukocytes to the peri\u2010implant mucosa (PIM) than to gingiva surrounding the teeth. This was accompanied by increased expression levels of IFN\u2010\u03b1, IL\u20101\u03b2, and RANKL\\OPG ratio. Interestingly, whereas repetitive infections resulted in bone loss around implants and teeth, a single infection induced bone loss only around implants, suggesting a higher susceptibility of the implants to infection. Treatment with RvD2 prevented <jats:italic>Pg<\/jats:italic>\u2010driven bone loss and reduced leukocyte infiltration to the PIM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Murine dental implants are associated with dysregulated local immunity and increase susceptibility to pathogen\u2010induced peri\u2010implantitis. However, the disease can be prevented by RvD2 treatment, highlighting the promising therapeutic potential of this treatment modality.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13631","type":"journal-article","created":{"date-parts":[[2022,6,28]],"date-time":"2022-06-28T06:23:38Z","timestamp":1656397418000},"page":"1217-1228","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Excessive inflammatory response to infection in experimental peri\u2010implantitis: Resolution by Resolvin <scp>D2<\/scp>"],"prefix":"10.1111","volume":"49","author":[{"given":"Oded","family":"Heyman","sequence":"first","affiliation":[{"name":"Department of Periodontology, Hadassah Medical Center, Faculty of Dental Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Horev","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Hadassah 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