{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T06:25:06Z","timestamp":1790922306860,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2022,6,10]],"date-time":"2022-06-10T00:00:00Z","timestamp":1654819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2022,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>This randomized placebo\u2010controlled clinical trial evaluated the effects of multispecies probiotic containing <jats:italic>Lactobacillus rhamnosus<\/jats:italic> HN001\u2122, <jats:italic>Lactobacillus paracasei<\/jats:italic> Lpc\u201037\u00ae, and <jats:italic>Bifidobacterium animalis<\/jats:italic> subsp <jats:italic>lactis<\/jats:italic> HN019\u2122 as an adjunct to mechanical debridement (MD) on changes in bleeding on probing (BOP) in edentulous patients with peri\u2010implant mucositis (PiM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients were randomly assigned to test (probiotic) or control (placebo) groups. All sites with PiM received MD and topical gel application (probiotic or placebo) at baseline and 12\u2009weeks. After initial MD, patients consumed probiotic or placebo capsules twice a day for 12\u2009weeks. Clinical (modified sulcus bleeding index [mSBI]; modified plaque index [mPI]; probing depth [PD]; and BOP) and immunological parameters were collected at baseline and after 12 and 24\u2009weeks. Data were statistically analysed (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six patients with PiM were recruited. The test group presented higher prevalence (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.05) of cases of restored peri\u2010implant health at 24\u2009weeks than did the control group (72.2% and 33.3%, respectively). No significant difference was observed between test (<jats:italic>n<\/jats:italic>\u00a0=\u200918) and control (<jats:italic>n<\/jats:italic>\u00a0=\u200918) groups for mPI and PD. mSBI %\u2014score 0 was higher in the test group than in the control group at 24\u2009weeks (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.05). When compared with baseline, both groups presented reduced BOP at 12 and 24\u2009weeks (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.05). BOP was lower in the test group than in the control group at 12 (mean difference\u00a0=\u00a0\u221214.54%; 95% confidence interval [CI]\u00a0=\u00a0\u221228.87 to 0.22; <jats:italic>p<\/jats:italic>\u00a0=\u2009.0163) and 24 (mean difference\u00a0=\u00a0\u221212.56%; 95% CI\u00a0=\u00a0\u221226.51 to 1.37; <jats:italic>p<\/jats:italic>\u00a0=\u2009.0090) weeks. At 24\u2009weeks, only the test group presented lower levels of interleukin (IL)\u20101\u03b2, IL\u20106, IL\u20108, and tumour necrosis factor (TNF)\u2010\u03b1 than those at baseline (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The multispecies probiotic (administered locally and systemically) containing <jats:italic>L. rhamnosus<\/jats:italic> HN001\u2122, <jats:italic>L. paracasei<\/jats:italic> Lpc\u201037\u00ae, and <jats:italic>B. lactis<\/jats:italic> HN019\u2122 as an adjunct to repeated MD promotes additional clinical and immunological benefits in the treatment of PiM in edentulous patients (ClinicalTrials.gov NCT04187222).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13663","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T07:37:51Z","timestamp":1653896271000},"page":"828-839","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Adjuvant use of multispecies probiotic in the treatment of peri\u2010implant mucositis: A randomized controlled trial"],"prefix":"10.1111","volume":"49","author":[{"given":"Sandro I.","family":"Santana","sequence":"first","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto University of Sao Paulo\u2014USP  Ribeirao Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7583-7046","authenticated-orcid":false,"given":"Pedro H. F.","family":"Silva","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto University of Sao Paulo\u2014USP  Ribeirao Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00e9rgio L.","family":"Salvador","sequence":"additional","affiliation":[{"name":"Department of Clinical Analyses, School of Pharmaceutical Sciences of Ribeirao Preto University of S\u00e3o Paulo\u2014USP  Ribeir\u00e3o Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1743-5855","authenticated-orcid":false,"given":"Renato C. V.","family":"Casarin","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics and Periodontics, School of Dentistry Campinas State University\u2014UNICAMP  Piracicaba S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fl\u00e1via A. C.","family":"Furlaneto","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto University of Sao Paulo\u2014USP  Ribeirao Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel R.","family":"Messora","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery and Periodontology, School of Dentistry of Ribeirao Preto University of Sao Paulo\u2014USP  Ribeirao Preto S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,10]]},"reference":[{"issue":"4","key":"e_1_2_12_2_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2017.11.011"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.12795"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2003.74.12.1736"},{"issue":"2","key":"e_1_2_12_6_1","first-page":"123","article-title":"Nonsurgical treatment for peri\u2010implant mucositis: A systematic review and meta\u2010analysis","volume":"13","author":"Barootchi S.","year":"2020","journal-title":"The International Journal of Oral Implantology"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.17-0739"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.11.962"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12334"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12013"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1995.tb00143.x"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12264"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12523"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12838"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdent.2016.03.002"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2015.1040065"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016357.2012.734406"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2012.01884.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-4388.73799"},{"key":"e_1_2_12_20_1","first-page":"128","article-title":"Antimicrobial treatment of peri\u2010implant diseases","volume":"19","author":"Heitz\u2010Mayfield L. 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