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The diabetes model was established using a high\u2010fat diet combined with streptozotocin injection. The periodontitis model was established by ligature combined with lipopolysaccharide (LPS) injection. Alveolar bones were analysed using micro\u2010computed tomography, histology, and immunohistochemistry. In vitro, human periodontal ligament cells (hPDLCs) were treated with LPS and high glucose. CRP knockdown lentivirus or CRP overexpression adenovirus combined with a PI3K\/AKT signalling inhibitor or agonist were used to explore the regulatory mechanism of CRP in osteogenesis and osteoclastogenesis of hPDLCs, as evidenced by alkaline phosphatase staining, Western blot, and quantitative polymerase chain reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In periodontitis and diabetes, CRP KO decreased the alveolar bone loss and the expression levels of osteoclastogenic markers, while increasing the expression levels of osteogenic markers. CRP constrained osteogenesis while promoting the osteoclastogenesis of hPDLCs via PI3K\/AKT signalling under high glucose and pro\u2010inflammatory conditions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CRP inhibits osteogenesis and promotes osteoclastogenesis via PI3K\/AKT signalling under diabetic and pro\u2010inflammatory conditions, thus perturbing alveolar bone homeostasis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13667","type":"journal-article","created":{"date-parts":[[2022,5,30]],"date-time":"2022-05-30T07:34:43Z","timestamp":1653896083000},"page":"1052-1066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["C\u2010reactive protein perturbs alveolar bone homeostasis: An experimental study of periodontitis and diabetes in the rat"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4446-4742","authenticated-orcid":false,"given":"Mengjiao","family":"Zhou","sequence":"first","affiliation":[{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory for Oral Biomedical Engineering of Higher Education, and Stomatological Hospital of Chongqing Medical University  Chongqing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaohui","family":"Xu","sequence":"additional","affiliation":[{"name":"Chongqing Key Laboratory for Oral Diseases and Biomedical Sciences Chongqing Municipal Key Laboratory for Oral Biomedical Engineering of Higher Education, and Stomatological Hospital of Chongqing Medical University  Chongqing 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