{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:29:50Z","timestamp":1790972990152,"version":"4.1.0"},"reference-count":76,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,21]],"date-time":"2022-07-21T00:00:00Z","timestamp":1658361600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100013590","name":"Alliance for California Traditional Arts","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013590","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001832","name":"Radboud Universiteit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001832","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>\u201cHost modulatory therapy\u201d (HMT) with \u03c9\u20103 fatty acids aims at reducing inflammation. With HMT as an adjunct, a better result of periodontal therapy is expected. The aim of this systematic review and meta\u2010analysis (MA) was to examine the additional effect of \u03c9\u20103 fatty acids to non\u2010surgical periodontal therapy (SRP) on the probing pocket depth (PPD) and the clinical attachment level (CAL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>MEDLINE\u2010PubMed and Cochrane\u2010CENTRAL libraries were searched up to January 2021 for randomized controlled trials in patients with chronic periodontitis, treated with SRP\/placebo as controls and SRP\/\u03c9\u20103 fatty acids as the test group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The search identified 173 unique abstracts, and screening resulted in 10 eligible publications. Descriptive analysis showed a significant effect on the PPD and CAL in favour of the groups with \u03c9\u20103 fatty acids in the majority of comparisons. MA revealed that adjunctive use of \u03c9\u20103 fatty acids to SRP resulted in 0.39\u2009mm more PPD reduction (95% CI: \u22120.58; \u22120.21) and 0.41\u2009mm more CAL gain (95% CI: \u22120.63; \u22120.19) than SRP alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In patients with periodontitis, dietary supplementation with \u03c9\u20103 fatty acids as an adjunct to SRP is more effective in reducing the PPD and improving the CAL than SRP alone. If SRP is indicated, the use of \u03c9\u20103 fatty acids can be considered for a moderate extra added effect on PPD reduction and CAL gain. The strength of this recommendation is moderate.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.13680","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T06:42:41Z","timestamp":1655448161000},"page":"1024-1037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["The effect of omega\u20103 fatty acids on active periodontal therapy: A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7339-3656","authenticated-orcid":false,"given":"Myrlon M.","family":"Van Ravensteijn","sequence":"first","affiliation":[{"name":"Department of Dentistry Radboudumc Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1432-6987","authenticated-orcid":false,"given":"Mark F.","family":"Timmerman","sequence":"additional","affiliation":[{"name":"Department of Dentistry Radboudumc Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ester A. G.","family":"Brouwer","sequence":"additional","affiliation":[{"name":"Department of Dentistry Radboudumc Nijmegen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7234-0037","authenticated-orcid":false,"given":"Dagmar Else","family":"Slot","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Academic Centre for Dentistry Amsterdam (ACTA) University of Amsterdam and Vrije Universiteit Amsterdam Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,21]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-3278(97)90421-X"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.6.1467S"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365513.2018.1516477"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamainternmed.2013.2299"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2010.08.002"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2006.11.020"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST0330423"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/83.6.1505S"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2009.01.008"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/0148607115595980"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.12984"},{"key":"e_1_2_13_13_1","unstructured":"Journal of Periodontology 91 Omega\u20103 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2021.10.005"},{"key":"e_1_2_13_15_1","unstructured":"Journal of Clinical Periodontology 40 Diabetes and periodontal diseases: consensus report of the Joint EFP\/AAP Workshop on Periodontitis and Systemic Diseases"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-91506-7"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2012.11.010"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2014.44.1.25"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/07315724.2013.875423"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13232"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2011.04.022"},{"key":"e_1_2_13_22_1","unstructured":"Journal of Periodontal Research 50 Effect of omega 3 fatty acids plus low\u2010dose aspirin on both clinical and biochemical profiles of patients with chronic periodontitis and type 2 diabetes: a randomized double blind placebo\u2010controlled study"},{"key":"e_1_2_13_23_1","first-page":"2815","article-title":"Scientific opinion on the tolerable upper intake level of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and docosapentaenoic acid (DPA)","volume":"10","author":"EFSA Panel on Dietetic Products NaA","year":"2012","journal-title":"EFSA Journal"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"e_1_2_13_25_1","first-page":"327","article-title":"Effect of omega\u20103 fatty acids on chronic periodontitis patients in postmenopausal women: A randomized controlled clinical study","volume":"4","author":"Elgendy E. 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