{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T11:15:16Z","timestamp":1788347716374,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071142"],"award-info":[{"award-number":["82071142"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071119"],"award-info":[{"award-number":["82071119"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>We investigated the role of long non\u2010coding RNAs and small nucleolar RNA host gene 5 (SNHG5) in the pathogenesis of periodontitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>A ligature\u2010induced periodontitis mouse model was established, and gingival tissues were collected from patients with periodontitis and healthy controls. Inflammatory cytokines were detected using quantitative reverse transcription\u2010polymerase chain reaction and western blotting analyses. Direct interactions between SNHG5 and p65 were detected by RNA pull\u2010down and RNA immunoprecipitation assays. Micro\u2010computed tomography, haematoxylin and eosin staining, and immunohistochemical staining were used to measure periodontal bone loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SNHG5 expression was down\u2010regulated in human and mouse periodontal tissues compared to that in the healthy controls. In vitro experiments demonstrated that SNHG5 significantly ameliorated tumour necrosis factor \u03b1\u2010induced inflammation. Mechanistically, SNHG5 directly binds to the nuclear factor\u2010kappa B (NF\u2010\u03baB) p65 subunit and inhibits its translocation, thereby suppressing the NF\u2010\u03baB signalling pathway activation and reducing the nucleotide\u2010binding oligomerization domain\u2010like receptor family pyrin domain\u2010containing three inflammasome expression. Locally injecting si\u2010SNHG5 aggravated the periodontal destruction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study revealed that SNHG5 mediates periodontal inflammation through the NF\u2010\u03baB signalling pathway, providing a potential therapeutic target for periodontitis treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13684","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T10:46:19Z","timestamp":1655462779000},"page":"1038-1051","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Long non\u2010coding <scp>RNA SNHG5<\/scp> mediates periodontal inflammation through the <scp>NF\u2010\u03baB<\/scp> signalling pathway"],"prefix":"10.1111","volume":"49","author":[{"given":"Yineng","family":"Han","sequence":"first","affiliation":[{"name":"Department of Orthodontics Peking University School and Hospital of Stomatology  Beijing People's 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