{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T23:25:07Z","timestamp":1790465107135,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,6]],"date-time":"2022-07-06T00:00:00Z","timestamp":1657065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The present pilot RCT aimed to investigate the influence of a connective tissue graft (CTG) in combination with the immediate implant placement (IIP) on hard and soft tissue healing, without a bone replacement graft in the gap between the implant and the socket walls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Thirty patients requiring extraction of one anterior tooth (from premolar to premolar) were randomly assigned to one of the two treatment groups (test: IIP\u2009+\u2009CTG; control: IIP). Cone\u2010beam computed tomography and optically scans were performed before tooth extraction and at 6\u2010month follow\u2010up. Then, DICOM files were superimposed in order to allow the evaluation of osseous ridge and buccal bone changes, while the superimposition of DICOM and Standard Tessellation Language files allowed for evaluating of soft tissue contour. For testing the differences between the two groups, the non\u2010parametric test as Wilcoxon rank\u2010sum test, was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six of the 30 enrolled patients attended the 6\u2010month follow\u2010up visit. The four patients of the control group that were lost to follow\u2010up were analysed under the intention\u2010to\u2010treat principle. No statistically significant differences between the groups were observed for the vertical buccal bone resorption (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.90), as well as for the horizontal buccal bone resorption at all measured levels. Significant differences were found between the test and control groups in the horizontal dimensional changes of osseous ridge at the most coronal aspect (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0003 and <jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). Changes in tissue contour were between \u22120.32 and \u22120.04\u2009mm in the test group and between \u22121.94 and \u22121.08\u2009mm in the control group, while changes in soft tissue thickness varied between 1.33 and 2.42\u2009mm in the test group and between \u22120.16 and 0.88\u2009mm in the control group, with statistically significant differences for both variables at all measured levels. At 6\u00a0months, the mean volume increase was 6.76\u2009\u00b1 8.94\u2009mm<jats:sup>3<\/jats:sup> and 0.16\u2009\u00b1\u20090.42\u2009mm<jats:sup>3<\/jats:sup> in the test and control groups, respectively, with a statistically significant difference.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of the present study indicate that the adjunct of a CTG at the time of IIP, without bone grafting, does not influence vertical bone resorption. Within the limits of this study, it can be suggested that the adjunct of a CTG at the time of IIP, without bone grafting, reduces the horizontal changes of the alveolar ridge. Moreover, it allows maintenance of the tissue contour due to an increase in soft tissue thickness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13685","type":"journal-article","created":{"date-parts":[[2022,6,17]],"date-time":"2022-06-17T10:46:08Z","timestamp":1655462768000},"page":"999-1011","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Soft and hard tissue changes after immediate implant placement with or without a sub\u2010epithelial connective tissue graft: Results from a 6\u2010month pilot randomized controlled clinical trial"],"prefix":"10.1111","volume":"49","author":[{"given":"Davide","family":"Guglielmi","sequence":"first","affiliation":[{"name":"Department of Periodontology Universit\u00e0 Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5956-2161","authenticated-orcid":false,"given":"Giovanna Laura","family":"Di Domenico","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universit\u00e0 Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8927-0303","authenticated-orcid":false,"given":"Sofia","family":"Aroca","sequence":"additional","affiliation":[{"name":"26K Center for Clinical Research  Paris France"},{"name":"Department of Periodontology Bern University  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4574-3671","authenticated-orcid":false,"given":"Fabio","family":"Vignoletti","sequence":"additional","affiliation":[{"name":"Thinking Perio Research  Verona Italy"},{"name":"Department of Periodontology, Faculty of Odontology Complutense University  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Ciaravino","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universit\u00e0 Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Donghia","sequence":"additional","affiliation":[{"name":"Department of Epidemiology National Institute of Gastroenterology \u201cS. De Bellis\u201d Research Hospital  Castellana Grotte Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5915-566X","authenticated-orcid":false,"given":"Massimo","family":"de Sanctis","sequence":"additional","affiliation":[{"name":"Department of Periodontology Universit\u00e0 Vita\u2010Salute San Raffaele  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,6]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12366"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2005.00726.x"},{"issue":"4","key":"e_1_2_11_4_1","article-title":"A novel surgical technique for soft tissue in a aesthetic areas of the mouth at implant placement","volume":"29","author":"Baldini A.","year":"2010","journal-title":"Journal de Parodontologia & d'Implantologie Orale"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2004.00565.x"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12775"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01842.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12295"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12167"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515592869"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13125"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1708-8208.2012.00448.x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/8822804"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12447"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2007.01413.x"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2009.01825.x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13331"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12027"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0501.2011.02372.x"},{"issue":"5","key":"e_1_2_11_20_1","first-page":"332","article-title":"Immediate implant placement into extraction sites: Surgical and restorative advantages","volume":"9","author":"Lazzara R. 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