{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T09:53:20Z","timestamp":1790848400382,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T00:00:00Z","timestamp":1658016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>Leucocyte\u2010 and platelet\u2010rich fibrin (L\u2010PRF) has been tested for enhancing alveolar ridge preservation (ARP), but little is known about the local release profile of growth factors (GF), and the clinical equipoise related to its efficacy remains. This study compared the patterns of GF release, early soft tissue healing, and alveolar ridge resorption following unassisted healing and L\u2010PRF application in non\u2010molar extraction sockets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Atraumatic tooth extraction of two hopeless teeth per patient was followed by unassisted healing or L\u2010PRF placement to fill the socket in 18 systemically healthy, non\u2010smoking subjects. This intra\u2010individual trial was powered to assess changes in horizontal alveolar ridge dimensions 1\u2009mm below the crest of alveolar bone. GF concentrations in wound fluid were assessed with a multiplex assay at 6, 24, 72, and 168\u2009h. Early healing was evaluated with the wound healing index and changes in soft tissue volumes on serial digital scans. Hard tissue changes were measured on superimposed CBCT images after 5\u00a0months of healing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>L\u2010PRF resulted in higher GF concentrations in wound fluid (WF) than in the control, but no differences in release patterns or time of peak were observed. No inter\u2010group differences in early healing parameters were observed. Alveolar bone resorption was observed in both groups. No significant inter\u2010group differences were observed in hard tissue healing 1, 3, or 5\u2009mm apical to the original bone crest or in the ability to digitally plan a prosthetically guided implant with or without bone augmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>L\u2010PRF increased the GF concentrations in WF of extraction sockets without shifting the pattern observed in unassisted healing, while the increased delivery did not translate into clinical benefits in early wound healing or ARP. The current findings question the assumption that increased local concentrations of GF by L\u2010PRF translate into improved clinical outcomes. Additional definitive studies are needed to establish the benefits of L\u2010PRF in ARP (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link> NCT03985033).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13688","type":"journal-article","created":{"date-parts":[[2022,6,23]],"date-time":"2022-06-23T07:40:07Z","timestamp":1655970007000},"page":"889-898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Increased local concentrations of growth factors from leucocyte\u2010 and platelet\u2010rich fibrin do not translate into improved alveolar ridge preservation: An intra\u2010individual mechanistic randomized controlled trial"],"prefix":"10.1111","volume":"49","author":[{"given":"Xuzhu","family":"Wang","sequence":"first","affiliation":[{"name":"Division of Periodontology and Implant Dentistry, Faculty of Dentistry The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6612-2866","authenticated-orcid":false,"given":"Melissa R.","family":"Fok","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Implant Dentistry, Faculty of Dentistry The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1917-1988","authenticated-orcid":false,"given":"George","family":"Pelekos","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Implant Dentistry, Faculty of Dentistry The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5340-9710","authenticated-orcid":false,"given":"Lijian","family":"Jin","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Implant Dentistry, Faculty of Dentistry The University of Hong Kong  Hong Kong SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2743-0137","authenticated-orcid":false,"given":"Maurizio S.","family":"Tonetti","sequence":"additional","affiliation":[{"name":"Division of Periodontology and Implant Dentistry, Faculty of Dentistry The University of Hong Kong  Hong Kong SAR China"},{"name":"Shanghai PerioImplant Innovation Center, Department of Oral and Maxillofacial Implantology, National Clinical Research Center of Stomatology, Ninth People's Hospital Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"European Research Group on Periodontology  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2017.170117"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13057"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12658"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13066"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13344"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12027"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/23259671211011948"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-019-03088-4"},{"issue":"2","key":"e_1_2_13_10_1","first-page":"181","article-title":"Efficacy of platelet\u2010rich fibrin on bone formation, part 1: Alveolar ridge preservation","volume":"14","author":"Miron R. 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