{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:24:20Z","timestamp":1747185860615,"version":"3.40.5"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,8,5]],"date-time":"2022-08-05T00:00:00Z","timestamp":1659657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the frequency of side effects associated with intake of metronidazole (MTZ)\u2009+\u2009amoxicillin (AMX) in periodontal treatment, and to explore associations between these events and patients' features.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Data of five randomized clinical trials testing MTZ\u2009+\u2009AMX adjunctive to mechanical therapy were evaluated. Volunteers answered an adverse event questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Information from 656 subjects was assessed. The frequency of side effects in the antibiotic\u2010 and placebo\u2010treated groups ranged from 1.0% to 17.7% and 0.9% to 13.7%, respectively. The events more frequently observed in the antibiotic than in the placebo group were diarrhoea and metallic taste (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.05). Diabetes significantly raised the odds of a patient reporting discomfort (odds ratio [OR]\u00a0=\u00a02.6), diarrhoea (OR\u00a0=\u00a04.0), weakness (OR\u00a0=\u00a06.0) and excessive sleepiness (OR\u00a0=\u00a02.9). In systemically healthy volunteers, using antibiotics 3\u00a0months post\u2010mechanical treatment (healing phase) (OR\u00a0=\u00a03.0), being a woman (OR\u00a0=\u00a03.9) and aged \u226449 (OR\u00a0=\u00a04.5) significantly increased the chances of reporting adverse events.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The occurrence of side effects during MTZ\u2009+\u2009AMX treatment ranged from uncommon (1%) to very common (17.7%). The main factors raising the chances of a patient reporting adverse events were diabetes and taking antibiotics in the healing phase, instead of in the active phase of treatment. Patients \u2264 49\u2009years old and females also tend to report more side effects.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13704","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T01:19:05Z","timestamp":1658193545000},"page":"1121-1132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Adverse events of metronidazole and amoxicillin: Retrospective analysis of a large data set of five randomized clinical trials"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1444-991X","authenticated-orcid":false,"given":"Belen","family":"Retamal\u2010Valdes","sequence":"first","affiliation":[{"name":"Department of Periodontology, Dental Research Division Guarulhos University  Guarulhos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula 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