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The primary outcome was mean root coverage (mRC) at 6\u00a0months. Complete root coverage, gain in gingival thickness (GT), keratinized tissue width, volumetric and ultrasonographic changes, and patient\u2010reported outcome measures were also assessed. Mixed\u2010modelling regression analyses were used for statistical comparisons.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 6\u00a0months, the mRC of the CCM\u2009+\u2009rhPDGF and CCM alone groups were 88.25% and 77.72%, respectively (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02). A significant gain in GT was consistently observed for both treatment arms, and more so for the patients receiving the matrix containing rhPDGF through time (0.51 vs. 0.80\u2009mm, on average, <jats:italic>p<\/jats:italic>\u00a0=\u00a0.01). The rhPDGF\u2009+\u2009CCM treated patients presented greater volume gain, higher soft tissue thickness, and a superior aesthetic score.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>rhPDGF enhances the clinical, volumetric, and aesthetic outcomes of MAGRs above the results achieved with CAF\u2009+\u2009CCM alone (ClinicalTrials.gov NCT04462237).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13706","type":"journal-article","created":{"date-parts":[[2022,7,25]],"date-time":"2022-07-25T01:49:17Z","timestamp":1658713757000},"page":"1169-1184","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["Recombinant human platelet\u2010derived growth factor improves root coverage of a collagen matrix for multiple adjacent gingival recessions: A triple\u2010blinded, randomized, placebo\u2010controlled 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