{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T15:59:45Z","timestamp":1792598385154,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007619","name":"Osteology Foundation","doi-asserted-by":"publisher","award":["YRG\u201015\u2010251"],"award-info":[{"award-number":["YRG\u201015\u2010251"]}],"id":[{"id":"10.13039\/501100007619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The present multi\u2010centre randomized clinical trial with 12\u2009months of follow\u2010up aimed at studying the added effect of sub\u2010marginal instrumentation before surgical treatment of peri\u2010implantitis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Forty\u2010two patients diagnosed with peri\u2010implantitis were recruited. After a behavioural intervention phase including oral hygiene instructions, patients were randomized to either receiving supra\u2010 and sub\u2010marginal instrumentation on their affected implants (control group: 21 patients and 29 implants) or only supra\u2010marginal instrumentation (test group: 21 patients and 24 implants), before undergoing surgery. Changes in the deepest probing pocket depth (PPD) with respect to baseline and a composite outcome of treatment success (no implant loss, no bone loss\u2009&gt;\u20090.5\u2009mm, no bleeding or suppuration on probing [BoP\/SoP], and PPD\u2009\u2264\u20095\u2009mm) at the 12\u2010month examination were regarded as the primary outcomes of the trial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At the 12\u2010month examination, changes in the deepest PPD with respect to baseline amounted to \u22122.96\u2009mm in the control group and to \u22123.11\u2009mm in the test one (MD\u00a0=\u00a0\u22120.16; SE\u00a0=\u00a00.56; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.769), while 21.4% of the implants in the control group and 33.3% in the test group presented treatment success (OR\u00a0=\u00a01.83; SE\u00a0=\u00a01.15; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.338). With the exception of a longer non\u2010surgical treatment duration in the control group (differences in \u00a0=\u00a0\u221214.29\u2009min; SE\u00a0=\u00a02.91; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001), no other secondary (e.g., soft\u2010tissue recession, keratinized mucosa height, and bone level changes, as well as BoP, SoP, profuse bleeding and implant loss rates) or exploratory (i.e., early wound healing, aesthetics, surgical and total treatment duration, surgery difficulty, intra\u2010operative bleeding, and adverse events) outcome demonstrated statistically significant differences between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The present multi\u2010centre randomized clinical trial did not demonstrate an added effect of performing sub\u2010marginal instrumentation 6\u2009weeks before the surgical treatment of peri\u2010implantitis. Larger clinical trials are however needed to confirm the present findings (Clinicaltrials.gov: NCT03620331).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13713","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T11:49:10Z","timestamp":1660132150000},"page":"1334-1345","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Effect of sub\u2010marginal instrumentation before surgical treatment of peri\u2010implantitis: A multi\u2010centre randomized clinical trial"],"prefix":"10.1111","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-083X","authenticated-orcid":false,"given":"Mario","family":"Romandini","sequence":"first","affiliation":[{"name":"Section of Post\u2010graduate Periodontology, Faculty of Odontology University Complutense  Madrid Spain"},{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010implant Diseases) Research Group University Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-5280","authenticated-orcid":false,"given":"Andreina","family":"Lafor\u00ed","sequence":"additional","affiliation":[{"name":"Department of Periodontology and Prosthodontics, \u201cGeorge Eastman\u201d Dental Hospital University Policlinic \u201cUmberto I\u201d  Rome Italy"},{"name":"Division of Fixed Prosthodontics and Biomaterials, Clinic of Dental Medicine University of Geneva  Geneva Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Pedrinaci","sequence":"additional","affiliation":[{"name":"Section of Post\u2010graduate Periodontology, Faculty of Odontology University Complutense  Madrid Spain"},{"name":"Department of Restorative Dentistry and Biomaterials Science, Harvard School of Dental Medicine Harvard University  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Baima","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, C.I.R. Dental School University of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Ferrarotti","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, C.I.R. 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