{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T19:08:31Z","timestamp":1787857711941,"version":"build-2784847793"},"reference-count":44,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the effect of periodontal treatment on HbA1c and diagnostic parameters of patients with metabolic syndrome (MetS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>One hundred and fifty\u2010eight patients with MetS and moderate and severe periodontitis were included. They were randomized into a test group (<jats:italic>n<\/jats:italic>\u00a0=\u200979), which received non\u2010surgical periodontal treatment, and a control group (<jats:italic>n<\/jats:italic>\u00a0=\u200979), which received no treatment. Medical treatment was delivered to both groups. Clinical periodontal, anthropometric and serological parameters were assessed at baseline, 3 and 6\u00a0months. The main outcome was glycated haemoglobin (HbA1c) levels, and the secondary outcomes were changes in the MetS parameters, C\u2010reactive protein (CRP) and HOMA indexes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant reductions in all periodontal parameters were observed in the test group, compared with the control group, at 3 and 6\u00a0months (<jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001). HbA1c levels, MetS parameters, CRP and HOMA indexes showed no significant differences between the test group and the control group at 3 and 6\u00a0months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Periodontal treatment led to a substantial reduction in periodontal inflammation, although there was no significant effect on the parameters used for MetS diagnosis in patients with early diagnosed and well\u2010controlled MetS.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13717","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T11:58:45Z","timestamp":1660132725000},"page":"11-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of periodontal treatment on glycated haemoglobin and metabolic syndrome parameters: A randomized clinical trial"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7541-3246","authenticated-orcid":false,"given":"Fernanda C.","family":"Milanesi","sequence":"first","affiliation":[{"name":"Post\u2010graduate Program in Dentistry: Periodontology Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6944-3238","authenticated-orcid":false,"given":"Bruna F.","family":"Greggianin","sequence":"additional","affiliation":[{"name":"Post\u2010graduate Program in Dentistry: Periodontology Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5364-5855","authenticated-orcid":false,"given":"Gabriela O.","family":"dos Santos","sequence":"additional","affiliation":[{"name":"Post\u2010graduate Program in Dentistry: Periodontology Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3852-3117","authenticated-orcid":false,"given":"Mirian P.","family":"Toniazzo","sequence":"additional","affiliation":[{"name":"Post\u2010graduate Program in Dentistry: Periodontology Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2013-8229","authenticated-orcid":false,"given":"Patricia","family":"Weidlich","sequence":"additional","affiliation":[{"name":"Department of Periodontology Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5873-9498","authenticated-orcid":false,"given":"Fernando","family":"Gerchman","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Hospital de Cl\u00ednicas de Porto Alegre Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4490-6088","authenticated-orcid":false,"given":"Rui V.","family":"Oppermann","sequence":"additional","affiliation":[{"name":"Department of Periodontology Federal University of Rio Grande do Sul  Porto Alegre Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,27]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1089\/met.2010.0002"},{"issue":"4","key":"e_1_2_10_3_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"#cr-split#-e_1_2_10_4_1.1","doi-asserted-by":"crossref","unstructured":"Alberti K. 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