{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T21:28:14Z","timestamp":1769549294792,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,19]],"date-time":"2022-10-19T00:00:00Z","timestamp":1666137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To histologically evaluate the influence of (1) loading and (2) grafting on osseointegration and peri\u2010implant soft\u2010tissue healing at immediately placed, self\u2010cutting progressive tissue\u2010level implants (TLX) in a minipig model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>TLX implants (<jats:italic>n<\/jats:italic>\u00a0=\u00a056) were immediately placed following the extraction of the mandibular first and second premolars, bilaterally, in a total of <jats:italic>n<\/jats:italic>\u00a0=\u00a014 minipigs. In each animal, the implant sites were allocated to the following four groups: (1) unloaded with simultaneous grafting using a bovine bone mineral; (2) unloaded without grafting; (3) loaded with simultaneous grafting; and (4) loaded without grafting. Histomorphometric assessments at 4 and 12\u2009weeks (<jats:italic>n<\/jats:italic>\u00a0=\u00a07 animals each) included primary (i.e., bone\u2010to\u2010implant contact [BIC]) and secondary outcome measures (e.g., first BIC [fBIC], junctional epithelium length [JE], connective tissue contact length [CTC], biological width [BW\u00a0=\u00a0JE\u2009+\u2009CTC]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At 4\u2009weeks, mean BIC values ranged from 74.5\u00a0\u00b1\u200911.6% in Group 2 to 83.8\u00a0\u00b1\u200913.3% in Group 1, and, at 12\u2009weeks, from 75.5%\u00a0\u00b1\u20097.9% in Group 2 to 79.9\u00a0\u00b1\u20098.6% in Group 1. Multivariate linear mixed regression did not reveal any associations between BIC and implant loading or grafting at 4 and 12\u2009weeks. At 12\u2009weeks, significantly higher fBIC values were noted in Group 2 when compared with Group 1. All groups showed comparable JE, CTC, and BW values.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Implant loading and grafting had no major effects on osseointegration and peri\u2010implant soft tissue healing at TLX implants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13734","type":"journal-article","created":{"date-parts":[[2022,10,11]],"date-time":"2022-10-11T06:47:14Z","timestamp":1665470834000},"page":"232-241","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Influence of loading and grafting on hard\u2010 and soft\u2010tissue healing at immediately placed implants: An experimental study in minipigs"],"prefix":"10.1111","volume":"50","author":[{"given":"Puria","family":"Parvini","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Implantology Carolinum, Goethe University  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Buser","sequence":"additional","affiliation":[{"name":"Buser Consulting Services  G\u00fcmligen Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7990-5555","authenticated-orcid":false,"given":"Benjamin Evans","family":"Pippenger","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"},{"name":"Department of Preclinical and Translational Research Institut Straumann AG  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean\u2010Claude","family":"Imber","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8161-3754","authenticated-orcid":false,"given":"Andreas","family":"Stavropoulos","sequence":"additional","affiliation":[{"name":"Department of Periodontology Malmo University  Malmo Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin","family":"Bell\u00f3n","sequence":"additional","affiliation":[{"name":"Department of Preclinical and Translational Research Institut Straumann AG  Basel Switzerland"},{"name":"Department of Periodontology, Faculty of Dentistry University of Zurich  Zurich Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Jarry","sequence":"additional","affiliation":[{"name":"Department of Global Medical Education Institut Straumann AG  Basel Switzerland"},{"name":"Department of Implantology Faculdade S\u00e3o Leopoldo Mandic  Campinas Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5515-227X","authenticated-orcid":false,"given":"Frank","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implantology Carolinum, Goethe University  Frankfurt 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