{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:35:56Z","timestamp":1791394556800,"version":"4.3.3"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,20]],"date-time":"2022-11-20T00:00:00Z","timestamp":1668902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the association between periodontal disease and atherosclerosis and to examine whether the association is modified by hypertension status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>In this cross\u2010sectional study, 1472 Japanese individuals aged 50\u201379\u2009years who underwent a medical check\u2010up, dental examination, and carotid ultrasonography were studied. Carotid atherosclerosis was expressed as the maximum and mean carotid intima\u2010media thickness (max\u2010IMT, mean\u2010IMT) and the presence of stenosis (\u226575%). Periodontal status was examined by the Community Periodontal Index (CPI, codes 0\u20134). The participants were divided into three groups according to the periodontal status (CPI0\u20132, CPI3, CPI4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A positive correlation was found between mean\u2010IMT and periodontal disease after adjustment for cardiovascular risk factors in the entire cohort (mean\u2010IMT in hypertensives: CPI0\u20132: 0.848\u2009mm, CPI3: 0.857\u2009mm, CPI4: 0.877\u2009mm; normotensives: 0.782, 0.802, 0.826). In the entire cohort, the multivariable\u2010adjusted odds ratio of stenosis based on mean\u2010IMT significantly increased according to periodontal status in normotensives (odds ratio; CPI0\u20132: 1, CPI3: 1.39, CPI4: 2.53; <jats:italic>p<\/jats:italic>\u2010value for trend\u00a0=\u00a0.004) but showed only marginal significant increase in hypertensives (1, 1.15, 1.55; <jats:italic>p<\/jats:italic>\u2010value for trend\u00a0=\u00a0.063). No significant relationships were observed for max\u2010IMT in all analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We observed an association between periodontal disease and atherosclerosis in normotensive and hypertensive participants.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13740","type":"journal-article","created":{"date-parts":[[2022,11,4]],"date-time":"2022-11-04T07:28:59Z","timestamp":1667546939000},"page":"265-275","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Relationship between carotid intima\u2010media thickness and periodontal disease in a Japanese urban population with and without hypertension: The Suita Study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9638-793X","authenticated-orcid":false,"given":"Momoyo","family":"Kida","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Gerodontology and Oral Rehabilitation Osaka University Graduate School of Dentistry  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Kokubo","sequence":"additional","affiliation":[{"name":"Department of Preventive Cardiology National Cerebral and Cardiovascular Centre  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3593-755X","authenticated-orcid":false,"given":"Takayuki","family":"Kosaka","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Gerodontology and Oral Rehabilitation Osaka University Graduate School of Dentistry  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takahiro","family":"Ono","sequence":"additional","affiliation":[{"name":"Division of Comprehensive Prosthodontics Niigata University Graduate School of Medical and Dental Sciences  Niigata 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