{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:04:53Z","timestamp":1791309893906,"version":"4.3.1"},"reference-count":55,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,11,18]],"date-time":"2022-11-18T00:00:00Z","timestamp":1668729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100019921","name":"Geistlich Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019921","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the healing outcomes in non\u2010molar post\u2010extraction sockets filled with deproteinized bovine bone mineral with collagen (DBBM\u2010C) as a function of time.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients in need of non\u2010molar tooth extraction were randomly allocated into one of three groups according to the total healing time (A\u20143\u00a0months; B\u20146\u00a0months; C\u20149\u00a0months). The effect of alveolar ridge preservation (ARP) therapy via socket filling using DBBM\u2010C and socket sealing with a porcine collagen matrix (CM) was assessed based on a panel of clinical, digital, histomorphometric, implant\u2010related, and patient\u2010reported outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 42 patients completed the study (<jats:italic>n<\/jats:italic>\u00a0=\u00a014 in each group). Histomorphometric analysis of bone core biopsies obtained at the time of implant placement showed a continuous increase in the proportion of mineralized tissue with respect to non\u2010mineralized tissue, and a decrease in the proportion of remaining xenograft material over time. All volumetric bone and soft tissue contour assessments revealed a dimensional reduction of the alveolar ridge overtime affecting mainly the facial aspect. Linear regression analyses indicated that baseline buccal bone thickness is a strong predictor of bone and soft tissue modelling. Ancillary bone augmentation at the time of implant placement was needed in 16.7% of the sites (A:2; B:1; C:4). Patient\u2010reported discomfort and wound healing index scores progressively decreased over time and was similar across groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Healing time influences the proportion of tissue compartments in non\u2010molar post\u2010extraction sites filled with DBBM\u2010C and sealed with a CM. A variable degree of alveolar ridge atrophy, affecting mainly the facial aspect, occurs even after performing ARP therapy. These changes are more pronounced in sites exhibiting thin facial bone (<jats:styled-content>\u2264<\/jats:styled-content>1\u2009mm) at baseline (<jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/clinicaltrials.gov\">Clinicaltrials.gov<\/jats:ext-link> NCT03659617).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13744","type":"journal-article","created":{"date-parts":[[2022,11,8]],"date-time":"2022-11-08T09:59:55Z","timestamp":1667901595000},"page":"132-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["Influence of healing time on the outcomes of alveolar ridge preservation using a collagenated bovine bone xenograft: A randomized clinical trial"],"prefix":"10.1111","volume":"50","author":[{"given":"Emilio","family":"Couso\u2010Queiruga","sequence":"first","affiliation":[{"name":"Department of Oral Surgery and Stomatology University of Bern School of Dental Medicine  Bern Switzerland"},{"name":"Department of Periodontics University of Iowa College of Dentistry  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Holly A.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Periodontics University of Iowa College of Dentistry  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Garaicoa\u2010Pazmino","sequence":"additional","affiliation":[{"name":"Department of Periodontics University of Iowa College of Dentistry  Iowa City Iowa USA"},{"name":"Investigation Center, School of Dentistry, Espiritu Santo University  Samborond\u00f3n Ecuador"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Barwacz","sequence":"additional","affiliation":[{"name":"Department of Family Dentistry University of Iowa College of Dentistry  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marisa","family":"Kalleme","sequence":"additional","affiliation":[{"name":"Division of Biostatistics and Computational Biology University of Iowa College of Dentistry  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Galindo\u2010Moreno","sequence":"additional","affiliation":[{"name":"Department of Oral Surgery and Implant Dentistry, School of Dentistry University of Granada  Granada Spain"},{"name":"Instituto de Investigaci\u00f3n Biosanitaria (IBS)  Granada Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo","family":"Avila\u2010Ortiz","sequence":"additional","affiliation":[{"name":"Department of Periodontics University of Iowa College of Dentistry  Iowa City Iowa USA"},{"name":"Department of Oral Medicine, Infection, and Immunity, Harvard School of Dental Medicine Harvard University  Boston Massachusetts USA"},{"name":"Private Practice, Atelier Dental Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,11,18]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","first-page":"205","article-title":"Augmentation of the deformed residual edentulous ridge for fixed prosthesis","volume":"1","author":"Abrams L.","year":"1980","journal-title":"The Compendium on Continuing Education in General Dentistry"},{"issue":"7","key":"e_1_2_12_3_1","first-page":"49","article-title":"Which hard tissue augmentation techniques are the most successful in furnishing bony support for implant placement?","volume":"22","author":"Aghaloo T. 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