{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:16:00Z","timestamp":1773011760000,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,11,29]],"date-time":"2022-11-29T00:00:00Z","timestamp":1669680000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100016988","name":"Biomedical Research Institute, Jeonbuk National University Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016988","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2021R1G1A1094681"],"award-info":[{"award-number":["2021R1G1A1094681"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","award":["2019R1C1C1010769"],"award-info":[{"award-number":["2019R1C1C1010769"]}],"id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The incidence of fungal sinusitis is increasing; however, its pathophysiology has not been investigated previously. We investigate the effect of periodontitis on the incidence of fungal sinusitis over a 12\u2010year follow\u2010up period using nationwide population\u2010based data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The periodontitis group was randomly selected from the National Health Insurance Service database. The non\u2010periodontitis group was obtained by propensity score matching considering several variables. The primary end point was the diagnosis of sinonasal fungal balls (SFBs) and invasive fungal sinusitis (IFS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The periodontitis and non\u2010periodontitis groups included 12,442 and 12,442 individuals, respectively. The overall adjusted hazard ratio (aHR) for SFBs in the periodontitis group was 1.46 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.002). In subgroup analysis, the aHR for SFBs was 1.59 (<jats:italic>p<\/jats:italic>\u00a0=\u00a00.008) for those with underlying chronic kidney disease (CKD), 1.58 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.022) for those with underlying atopic dermatitis, 1.48 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.019) for those with chronic obstructive pulmonary disease (COPD), and 1.36 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.030) for those with diabetes mellitus (DM), but these values are applicable only when considering the relationship between periodontitis and SFB. The aHR for IFS in the periodontitis group was higher than in the non\u2010periodontitis group (2.80; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.004).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The risk of SFBs and IFS increased after diagnosis of periodontitis. This trend is often more severe in patients with DM, COPD, or CKD, but this association with underlying diseases is applicable only when considering the association between periodontitis and fungal sinusitis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13753","type":"journal-article","created":{"date-parts":[[2022,11,23]],"date-time":"2022-11-23T07:01:00Z","timestamp":1669186860000},"page":"440-451","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Periodontitis is associated with the development of fungal sinusitis: A nationwide 12\u2010year follow\u2010up study"],"prefix":"10.1111","volume":"50","author":[{"given":"Min Gul","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Pharmacology Jeonbuk National University Medical School  Jeonju Republic of Korea"},{"name":"Research Institute of Clinical Medicine of Jeonbuk National University \u2013 Biomedical Research Institute of Jeonbuk National University Hospital  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Gu","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics Jeonbuk National University Medical School  Jeonju Republic of Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Jeonbuk National University Medical School  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Gyu","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics Jeonbuk National University Medical School  Jeonju Republic of Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Jeonbuk National University Medical School  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seong J.","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Statistics (Institute of Applied Statistics) Jeonbuk National University  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Woo","family":"Yeom","sequence":"additional","affiliation":[{"name":"Department of Medical Informatics Jeonbuk National University Medical School  Jeonju Republic of Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Jeonbuk National University Medical School  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9083-9392","authenticated-orcid":false,"given":"Jong Hwan","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Jeonbuk National University Medical School  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Moon","family":"Choi","sequence":"additional","affiliation":[{"name":"Doctors Dental Clinic  Gunsan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hyun","family":"Yoon","sequence":"additional","affiliation":[{"name":"Sae Bom Dental Clinic  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Jung","family":"Lee","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical Medicine of Jeonbuk National University \u2013 Biomedical Research Institute of Jeonbuk National University Hospital  Jeonju Republic of Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Jeonbuk National University Medical School  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Jae","family":"Noh","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical Medicine of Jeonbuk National University \u2013 Biomedical Research Institute of Jeonbuk National University Hospital  Jeonju Republic of Korea"},{"name":"Department of Forensic Medicine Jeonbuk National University Medical School  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min\u2010Su","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery, CHA Bundang Medical Center CHA University School of Medicine  Bundang Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jong Seung","family":"Kim","sequence":"additional","affiliation":[{"name":"Research Institute of Clinical Medicine of Jeonbuk National University \u2013 Biomedical Research Institute of Jeonbuk National University Hospital  Jeonju Republic of Korea"},{"name":"Department of Medical Informatics Jeonbuk National University Medical School  Jeonju Republic of Korea"},{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Jeonbuk National University Medical School  Jeonju Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,11,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-02032-x"},{"key":"e_1_2_13_3_1","volume-title":"StatPearls [internet]","author":"Akhondi H.","year":"2021"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12729"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joen.2010.01.016"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bjorl.2015.07.013"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3785"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2018.21554"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15452"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmed.2021.106640"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000030174"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/coa.12588"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-022-07125-8"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2011.01808.x"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2021011576"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12808"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13334"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.766944"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00405-018-5258-z"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13414"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/myc.13484"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12895-020-00117-8"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13670"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.4HI1221-722R"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/20587392211002411"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.7326\/M16-2607"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2021.782805"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.5664\/jcsm.9352"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/alr.22007"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2021.11.002"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-021-01737-3"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-012-9439-0"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13753","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpe.13753","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13753","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T01:00:55Z","timestamp":1705798855000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.13753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,11,29]]},"references-count":31,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/jcpe.13753"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.13753","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,11,29]]},"assertion":[{"value":"2022-08-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}