{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T23:01:40Z","timestamp":1792450900088,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003559","name":"Ministry of National Defense","doi-asserted-by":"publisher","award":["MND\u2010MAB\u2010110\u2010124"],"award-info":[{"award-number":["MND\u2010MAB\u2010110\u2010124"]}],"id":[{"id":"10.13039\/501100003559","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003559","name":"Ministry of National Defense","doi-asserted-by":"publisher","award":["MND\u2010MAB\u2010110\u2010127"],"award-info":[{"award-number":["MND\u2010MAB\u2010110\u2010127"]}],"id":[{"id":"10.13039\/501100003559","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To use experimental periodontitis models in rats to investigate the correlation between local expression of the complement components C3b and C4b in periodontal tissues and disease severity, and to assess the therapeutic effects of targeting C3b\/C4b on inflammatory bone loss.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>The gingival expression of C3, C3b, and C4b in animal experimental periodontitis models were analysed immunohistochemically. The therapeutic effects of the C3b\/C4b inhibitor (SB002) on ligation\u2010induced experimental periodontitis was examined using biochemical, histological, and immunohistochemical analyses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The gingival expression levels of C3, C3b, and C4b were positively correlated with the severity of periodontitis. Moreover, both single and multiple injections of the C3b\/C4b inhibitor had preventive and therapeutic effects on alveolar bone loss in ligation\u2010induced experimental periodontitis with no associated adverse consequences.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The association between C3b\/C4b and periodontitis may provide a basis for the development of novel therapeutic strategies for periodontitis and other inflammatory diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13772","type":"journal-article","created":{"date-parts":[[2023,1,12]],"date-time":"2023-01-12T05:53:45Z","timestamp":1673502825000},"page":"657-670","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Targeting therapeutic agent against C3b\/C4b, <scp>SB002<\/scp>, on the inflammation\u2010induced bone loss in experimental periodontitis"],"prefix":"10.1111","volume":"50","author":[{"given":"Ren\u2010Yeong","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dentistry Tri\u2010Service General Hospital and National Defense Medical Center  Taipei Taiwan"},{"name":"Graduate Institutes of Dental Sciences, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang\u2010Yi","family":"Tseng","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry Tri\u2010Service General Hospital and National Defense Medical Center  Taipei Taiwan"},{"name":"Graduate Institutes of Dental Sciences, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jhong\u2010Jhe","family":"You","sequence":"additional","affiliation":[{"name":"AP Biosciences, Inc.  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E.","family":"Van Dyke","sequence":"additional","affiliation":[{"name":"Oral Medicine, Infection, and Immunity Harvard School of Dental Medicine  Boston Massachusetts USA"},{"name":"Department of Applied Oral Sciences The Forsyth Institute  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chia\u2010Dan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry Tri\u2010Service General Hospital and National Defense Medical Center  Taipei Taiwan"},{"name":"Graduate Institutes of Dental Sciences, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0038-6172","authenticated-orcid":false,"given":"Cheng\u2010En","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry Tri\u2010Service General Hospital and National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei\u2010Wei","family":"Weng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics Shuang Ho Hospital, Taipei Medical University  New Taipei City Taiwan"},{"name":"Department of Orthopaedics College of Medicine, Taipei Medical University  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Shing","family":"Shieh","sequence":"additional","affiliation":[{"name":"Graduate Institutes of Dental Sciences, National Defense Medical Center  Taipei Taiwan"},{"name":"Department of Operative Dentistry and Endodontics, School of Dentistry Tri\u2010Service General Hospital and National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Chien","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dentistry Tri\u2010Service General Hospital and National Defense Medical Center  Taipei Taiwan"},{"name":"Graduate Institutes of Dental Sciences, National Defense Medical Center  Taipei Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202339"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12169"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.2010.01301.x"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12296"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12222"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.21767\/2573-5365.100037"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2007.07.006"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000329675"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00406"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/omi.12161"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2011.10.006"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI152973"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20041967"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1402892"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0089-x"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molimm.2007.06.006"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12297"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1400569"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12507"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.05.012"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2016.01.025"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0801191"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.1989.tb01609.x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000316"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0602-582"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12148"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.97"},{"issue":"3","key":"e_1_2_11_29_1","first-page":"138","article-title":"Recommendation for uniform definition of an immunoreactive score (IRS) for immunohistochemical estrogen receptor detection (ER\u2010ICA) in breast cancer tissue","volume":"8","author":"Remmele W.","year":"1987","journal-title":"Pathologe"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1923"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203487"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2016.70"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1977.48.12.778"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2006.01886.x"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.2741\/2669"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.02.001"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13264"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2017.04.006"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0088"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00511"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2015.02.001"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.2000697"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2014.05.009"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13772","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpe.13772","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13772","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T01:11:05Z","timestamp":1705799465000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.13772"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,29]]},"references-count":42,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1111\/jcpe.13772"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.13772","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,29]]},"assertion":[{"value":"2022-11-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}