{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T20:52:01Z","timestamp":1787863921221,"version":"build-2784847793"},"reference-count":46,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,29]],"date-time":"2023-01-29T00:00:00Z","timestamp":1674950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate subgingival instrumentation (SI) in periodontitis stage III and IV, grade B and C with systemic antibiotics (AB) only after detection of <jats:italic>Aggregatibacter actinomycetemcomitans<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients of the Department of Periodontology of Goethe University Frankfurt\/Germany were screened for microbiological testing between 2008 and 2018. All patients with aggressive and generalized severe chronic periodontitis were tested. In case of positive subgingival <jats:italic>A. actinomycetemcomitans<\/jats:italic> tests<jats:italic>,<\/jats:italic> SI was combined with AB; in all other cases it was not (nAB). Clinical examinations were performed before (T0), 12.4 (9.4\/15.1) weeks after SI (T1), and at the last supportive periodontal care (T2; 3.1 [1.4\/5.5] years after T1). Results at T1\/T2 were assessed as \u201ctreat\u2010to\u2010target\u201d endpoint (\u22644 sites with probing pocket depths \u22655\u2009mm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Four\u2010hundred and twenty\u2010five patients (280 stage III\/145 stage IV, 95 grade B\/330 grade C) provided complete data (AB 144\/nAB 281) for T0 and T1, and 332 (AB 121\/nAB 211) for T2. At T1\/T2, AB resulted in 53 (37%)\/76 (63%) patients with \u201ctreat\u2010to\u2010target\u201d endpoint, and nAB in 76 (27%)\/91 (43%) (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.038\/.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In periodontitis stage III and IV, grade B and C with subgingival <jats:italic>A. actinomycetemcomitans<\/jats:italic> infection, SI with AB resulted in higher rate of \u201ctreat\u2010to\u2010target\u201d endpoint than exclusive SI in patients without the infection.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13777","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T08:08:06Z","timestamp":1673856486000},"page":"684-693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Additional benefit of systemic antibiotics in subgingival instrumentation of stage <scp>III<\/scp> and <scp>IV<\/scp> periodontitis with <i>Aggregatibacter actinomycetemcomitans<\/i>: A retrospective analysis"],"prefix":"10.1111","volume":"50","author":[{"given":"Leander","family":"Benz","sequence":"first","affiliation":[{"name":"Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main  Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrizia","family":"Winkler","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main  Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1054-0479","authenticated-orcid":false,"given":"Bettina","family":"Dannewitz","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main  Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3785-8364","authenticated-orcid":false,"given":"Katrin","family":"Nickles","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main  Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8901-8017","authenticated-orcid":false,"given":"Hari","family":"Petsos","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main  Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talal","family":"Aldiri","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main  Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-8055","authenticated-orcid":false,"given":"Peter","family":"Eickholz","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum) Johann Wolfgang Goethe\u2010University Frankfurt\/Main  Frankfurt\/Main Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12345"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_12_4_1","first-page":"263","article-title":"Adjuvantive Antibiotikagabe in der Parodontitistherapie. 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