{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T09:00:49Z","timestamp":1791536449610,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T00:00:00Z","timestamp":1674777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To study the epidemiological association between periodontitis and low cognitive performance among older adults, within a representative sample of the U.S. population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Data from 2086 older adults (\u226560\u2009years old), representative of 77.1\u00a0million people, were retrieved from the NHANES 2011\u20102014 database. Periodontitis cases were identified and classified according to the AAP\/CDC criteria (mild, moderate, and severe). Cognitive function was assessed through the Consortium to Establish a Registry for Alzheimer's disease (CERAD), the animal fluency test (AFT), the digit symbol substitution test (DSST), and the global cognition score. The lowest non\u2010survey weighted quartile for each cognitive test was defined as low cognitive performance. Simple and multiple regression analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Moderate and severe periodontitis were significantly associated with a low DSST performance (OR\u00a0=\u00a01.66 and OR\u00a0=\u00a02.97, respectively). Each millimetre increase in mean CAL was associated with a lower AFT (OR\u00a0=\u00a01.44), DSST (OR\u00a0=\u00a01.86), and global cognition (OR\u00a0=\u00a01.50) performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The findings of the present study suggest the existence of an independent association between periodontitis and low cognitive performance among older adults (\u226560\u2009years old).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13779","type":"journal-article","created":{"date-parts":[[2023,1,16]],"date-time":"2023-01-16T08:07:05Z","timestamp":1673856425000},"page":"418-429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Periodontitis and low cognitive performance: A population\u2010based study"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1088-2046","authenticated-orcid":false,"given":"Crystal","family":"Marruganti","sequence":"first","affiliation":[{"name":"Unit of Periodontology, Endodontology and Restorative Dentistry, Department of Medical Biotechnologies University of Siena  Siena Italy"},{"name":"Department of Surgical, Medical and Molecular Pathology and Critical Care Medicine University of Pisa  Pisa Italy"},{"name":"Sub\u2010Unit of Periodontology, Halitosis and Periodontal Medicine University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Baima","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, C.I.R. Dental School University of Turin  Turin Italy"},{"name":"University of Turin Polytechnic of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0657-0787","authenticated-orcid":false,"given":"Mario","family":"Aimetti","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences, C.I.R. Dental School University of Turin  Turin Italy"},{"name":"University of Turin Polytechnic of Turin  Turin Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simone","family":"Grandini","sequence":"additional","affiliation":[{"name":"Unit of Periodontology, Endodontology and Restorative Dentistry, Department of Medical Biotechnologies University of Siena  Siena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariano","family":"Sanz","sequence":"additional","affiliation":[{"name":"Faculty of Odontology University Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5646-083X","authenticated-orcid":false,"given":"Mario","family":"Romandini","sequence":"additional","affiliation":[{"name":"Faculty of Odontology University Complutense  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,27]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13611"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jre.13061"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345221104725"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211037977"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-200064"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81705-7"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehz646"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-8587(18)30038-X"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000010312"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0160-5"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-019-0777-6"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110664"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30925-9"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12344"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-020-00488-6"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0158845"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/00220345211043461"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12429"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-75517-4"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-190263"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30367-6"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13766"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ahj.2016.07.018"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S37929"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2013.10.011"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0276"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.39.9.1159"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvz201"},{"key":"e_1_2_12_31_1","unstructured":"National Health and Nutrition Examination Survey.2011\u20132012 Data documentation codebook and frequencies cognitive functioning. 15 March 2022.https:\/\/wwwn.cdc.gov\/Nchs\/Nhanes\/2011-2012\/CFQ_G.htm"},{"key":"e_1_2_12_32_1","unstructured":"National Health and Nutrition Examination Survey.2013\u20132014 Data documentation codebook and frequencies cognitive functioning. 15 March 2022.https:\/\/wwwn.cdc.gov\/Nchs\/Nhanes\/2013-2014\/CFQ_H.htm"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30403-4"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12992"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034520952401"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12713"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13004"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13248"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-1185-4_2"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13189"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12304"},{"key":"e_1_2_12_42_1","volume-title":"A compendium of neuropsychological tests: Administration, norms, and commentary","author":"Strauss E.","year":"2006"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13507"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13155"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2018.3"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijsu.2014.07.014"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(07)61602-x"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.10575"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(19)30079-1"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(16)00062-4"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.63"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-017-1052-x"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-215250"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13779","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jcpe.13779","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,21]],"date-time":"2024-01-21T01:01:09Z","timestamp":1705798869000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.13779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,27]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1111\/jcpe.13779"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.13779","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,27]]},"assertion":[{"value":"2022-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}