{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T12:59:48Z","timestamp":1781528388425,"version":"3.54.1"},"reference-count":53,"publisher":"Wiley","issue":"S26","license":[{"start":{"date-parts":[[2023,3,6]],"date-time":"2023-03-06T00:00:00Z","timestamp":1678060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To answer the following PICO question: In systemically healthy humans with peri\u2010implant mucositis, what is the efficacy of patient\u2010performed or administered (by prescription) measures used adjunctively to submarginal instrumentation, as compared to submarginal instrumentation alone or combined with a negative control, in terms of reducing bleeding on probing (BOP), in randomized controlled clinical trials (RCTs) with at least 3 months of follow\u2010up?<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Three databases were searched until April 2022. Weighted mean differences (WMDs) with 95% confidence intervals (CIs) and predictive intervals were calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixteen parallel RCTs corresponding to 14 studies with low\/moderate risk of bias were included. Test groups showed greater reductions in BOP (%) than control groups (<jats:italic>n<\/jats:italic><jats:sub>studies<\/jats:sub>\u00a0=\u00a016; <jats:italic>n<\/jats:italic><jats:sub>patients<\/jats:sub>\u00a0=\u00a0650; WMD\u00a0=\u00a014.25%; 95% CI [9.06\u201319.45]; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u200998.7%). The greatest WMD in BOP reductions (%) were obtained by antiseptics (<jats:italic>n<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u00a0=\u00a05; <jats:italic>n<\/jats:italic><jats:sub><jats:italic>p<\/jats:italic><\/jats:sub>\u00a0=\u00a0229; WMD\u00a0=\u00a022.72%; 95% CI [19.40\u201326.04]; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u200994.8%), followed by probiotics (<jats:italic>n<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u00a0=\u00a06; <jats:italic>n<\/jats:italic><jats:sub><jats:italic>p<\/jats:italic><\/jats:sub>\u00a0=\u00a0260; WMD\u00a0=\u00a012.11%; 95% CI [3.20\u201321.03]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.008; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u200993.3%) and systemic antibiotics (<jats:italic>n<\/jats:italic><jats:sub><jats:italic>s<\/jats:italic><\/jats:sub>\u00a0=\u00a03; <jats:italic>n<\/jats:italic><jats:sub><jats:italic>p<\/jats:italic><\/jats:sub>\u00a0=\u00a0101; WMD\u00a0=\u00a05.97%; 95% CI [1.34\u201310.59]; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.012; <jats:italic>I<\/jats:italic><jats:sup>2<\/jats:sup>\u00a0=\u200958.1%). Disease resolution was scarcely reported (<jats:italic>n<\/jats:italic>\u00a0=\u00a06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Significant clinical improvements can be obtained when professional submarginal instrumentation is combined with patient\u2010performed or administered (by prescription) adjunctive measures, although a complete disease resolution may not be achieved.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13791","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:39:36Z","timestamp":1676507976000},"page":"161-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Efficacy of adjunctive measures in peri\u2010implant mucositis. A systematic review and meta\u2010analysis"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1554-9966","authenticated-orcid":false,"given":"Stefano","family":"Gennai","sequence":"first","affiliation":[{"name":"Department of Surgical Medical and Molecular Pathology and Critical Care Medicine, University of Pisa  Pisa Italy"},{"name":"Sub\u2010Unit of Periodontology Halitosis and Periodontal Medicine, University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Bollain","sequence":"additional","affiliation":[{"name":"Section of Periodontology, Department of Dental Clinical Specialties Complutense University of Madrid  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nagore","family":"Ambrosio","sequence":"additional","affiliation":[{"name":"Section of Periodontology, Department of Dental Clinical Specialties Complutense University of Madrid  Madrid 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Medical and Molecular Pathology and Critical Care Medicine, University of Pisa  Pisa Italy"},{"name":"Sub\u2010Unit of Periodontology Halitosis and Periodontal Medicine, University Hospital of Pisa  Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-1416","authenticated-orcid":false,"given":"Elena","family":"Figuero","sequence":"additional","affiliation":[{"name":"Section of Periodontology, Department of Dental Clinical Specialties Complutense University of Madrid  Madrid Spain"},{"name":"ETEP (Etiology and Therapy of Periodontal and Peri\u2010Implant Diseases) Research Group, Complutense University of Madrid  Madrid 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