{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T07:17:20Z","timestamp":1789888640444,"version":"4.0.1"},"reference-count":35,"publisher":"Wiley","issue":"S26","license":[{"start":{"date-parts":[[2023,3,12]],"date-time":"2023-03-12T00:00:00Z","timestamp":1678579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To answer the following PICOS question: \u201cIn adult patients with peri\u2010implantitis, what is the efficacy of surgical therapy with chemical surface decontamination of implant surfaces in comparison with surgical therapy alone or surgery with placebo decontamination, on probing pocket depth (PD) reduction and bleeding on probing (BoP)\/suppuration on probing (SoP), in randomized controlled clinical trials (RCTs) and non\u2010RCTs with at least 6\u00a0months of follow\u2010up?\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Six databases were searched from their inception up to 20 May 2022. Data on clinical outcome variables were pooled and analysed using mean differences (MDs), risk ratios (RRs), or risk differences (RDs) as appropriate, 95% confidence intervals (CIs), and prediction intervals (PIs) in the case of significant heterogeneity. Primary outcomes were determined as changes in PD and BoP\/SoP. Secondary outcomes were radiographic marginal bone loss (MBL), implant loss, and disease resolution. PROSPERO registration number: CRD42022325603.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Six RCTs\u2014two with moderate, three with high, and one with low risk of bias (RoB)\u2014were included. These studies test the adjunctive effect of photodynamic therapy (PDT), chlorhexidine (CHX), and administration of local antibiotics (LAbs) during surgery on the clinical outcome. In a single 12\u2010month study, the adjunctive use of local antibiotics showed a clinically relevant reduction of PD [MD\u00a0=\u00a01.44; 95%CI (0.40 to \u22122.48)] and MBL [MD\u00a0=\u00a01.21; 95%CI (0.44\u20131.98); one trial, 32 participants]. PDT showed a small but significant reduction in BoP [MD\u00a0=\u00a07.41%; 95%CI (0.81\u201314.00); <jats:italic>p<\/jats:italic>\u00a0=\u20090.028; two trials; 42 participants]. Treatment with CHX resulted in no significant changes in PD, BoP, or MBL compared to placebo (saline solution). None of the interventions affected disease resolution and implant loss. Certainty of the evidence was very low for all outcome measures assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Within the limitations of this systematic review and the meta\u2010analysis, adjunctive use of chemicals such as PDT, CHX, and LAbs for surface decontamination during surgery of peri\u2010implantitis cannot be recommended as superior to standard debridement procedures (mechanical debridement with or without saline).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13794","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:44:50Z","timestamp":1676508290000},"page":"336-358","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["The efficacy of implant surface decontamination using chemicals during surgical treatment of peri\u2010implantitis: A systematic review and <scp>meta\u2010analysis<\/scp>"],"prefix":"10.1111","volume":"50","author":[{"given":"Asaf","family":"Wilensky","sequence":"first","affiliation":[{"name":"Department of Periodontology, Hadassah Medical Center, Faculty of Dental Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9145-5155","authenticated-orcid":false,"given":"Lior","family":"Shapira","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Hadassah Medical Center, Faculty of Dental Medicine Hebrew University of Jerusalem  Jerusalem Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1214-8286","authenticated-orcid":false,"given":"Alvaro","family":"Limones","sequence":"additional","affiliation":[{"name":"Department of Conservative and Prosthetic Dentistry, Faculty of Dentistry Complutense University of Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3997-6900","authenticated-orcid":false,"given":"Conchita","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Dental Clinical Specialties, Faculty of Dentistry Complutense University of Madrid (UCM)  Madrid Spain"},{"name":"BIOCRAN Research group Complutense University of Madrid (UCM)  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,12]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2018.05.003"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13607"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12957"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.id.0000433592.18679.91"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515601961"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2015.12.007"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/0022034518818479"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.ED000142"},{"issue":"4","key":"e_1_2_11_10_1","first-page":"321","article-title":"The effectiveness of adjunctive light\u2010activated disinfection (LAD) in the treatment of peri\u2010implantitis: 4\u2010month results from a multicentre pragmatic randomised controlled trial. 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