{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T19:57:52Z","timestamp":1790452672474,"version":"4.1.0"},"reference-count":41,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,3,28]],"date-time":"2023-03-28T00:00:00Z","timestamp":1679961600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y20190102"],"award-info":[{"award-number":["Y20190102"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["Y2020116"],"award-info":[{"award-number":["Y2020116"]}],"id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81901015"],"award-info":[{"award-number":["81901015"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81870777"],"award-info":[{"award-number":["81870777"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82104175"],"award-info":[{"award-number":["82104175"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270991"],"award-info":[{"award-number":["82270991"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To investigate whether silibinin impacts diabetic periodontitis (DP) via mitochondrial regulation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>\n                      In vivo, rats were divided into control, diabetes,\n                      <jats:styled-content style=\"fixed-case\">DP<\/jats:styled-content>\n                      and\n                      <jats:styled-content style=\"fixed-case\">DP<\/jats:styled-content>\n                      combined with silibinin groups. Diabetes and periodontitis were induced by streptozocin and silk ligation, respectively. Bone turnover was evaluated by microcomputed tomography, histology and immunohistochemistry. In vitro, human periodontal ligament cells (\n                      <jats:styled-content style=\"fixed-case\">hPDLCs<\/jats:styled-content>\n                      ) were exposed to hydrogen peroxide (\n                      <jats:styled-content style=\"fixed-case\">\n                        H\n                        <jats:sub>2<\/jats:sub>\n                        O\n                        <jats:sub>2<\/jats:sub>\n                      <\/jats:styled-content>\n                      ) with or without silibinin. Osteogenic function was analysed by Alizarin Red and alkaline phosphatase staining. Mitochondrial function and biogenesis were investigated by mitochondrial imaging assays and quantitative polymerase chain reaction. Activator and lentivirus\u2010mediated knockdown of peroxisome proliferator\u2010activated receptor gamma\u2010coactivator 1\u2010alpha (\n                      <jats:styled-content style=\"fixed-case\">PGC<\/jats:styled-content>\n                      \u20101\u03b1), a critical regulator of mitochondria biogenesis, was used to explore the mitochondrial mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Silibinin attenuated periodontal destruction and mitochondrial dysfunction and enhanced mitochondrial biogenesis and PGC\u20101\u03b1 expression in rats with DP. Meanwhile, silibinin promoted cell proliferation, osteogenesis and mitochondrial biogenesis and increased the PGC\u20101\u03b1 level in hPDLCs exposed to H\n                      <jats:sub>2<\/jats:sub>\n                      O\n                      <jats:sub>2<\/jats:sub>\n                      . Silibinin also protected PGC\u20101\u03b1 from proteolysis in hPDLCs. Furthermore, both silibinin and activator of PGC\u20101\u03b1 ameliorated cellular injury and mitochondrial abnormalities in hPDLCs, while knockdown of PGC\u20101\u03b1 abolished the beneficial effect of silibinin.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Silibinin attenuated DP through the promotion of PGC\u20101\u03b1\u2010dependent mitochondrial biogenesis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jcpe.13811","type":"journal-article","created":{"date-parts":[[2023,3,20]],"date-time":"2023-03-20T19:43:27Z","timestamp":1679341407000},"page":"964-979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Activation of\n                    <scp>PGC<\/scp>\n                    \u20101\u03b1\u2010dependent mitochondrial biogenesis supports therapeutic effects of silibinin against type I diabetic periodontitis"],"prefix":"10.1111","volume":"50","author":[{"given":"Xiaoyu","family":"Sun","sequence":"first","affiliation":[{"name":"Institute of Stomatology, School and Hospital of Stomatology Wenzhou Medical University  Wenzhou China"},{"name":"Department of Periodontics, School and Hospital of Stomatology Wenzhou Medical University  Wenzhou China"},{"name":"Department of Prosthetic and Implantology, Amsterdam UMC and Academic Centre for Dentistry Amsterdam (ACTA) Vrije Universiteit Amsterdam (VUA), Amsterdam Movement Science  de Boelelaan 1117 Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Ping","sequence":"additional","affiliation":[{"name":"Institute of Stomatology, School and Hospital of Stomatology Wenzhou Medical University  Wenzhou China"},{"name":"Department of Prosthodontics, School and Hospital of Stomatology Wenzhou Medical University  Wenzhou 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