{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T16:15:10Z","timestamp":1760890510785,"version":"3.40.5"},"reference-count":46,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2023,4,12]],"date-time":"2023-04-12T00:00:00Z","timestamp":1681257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To assess the long\u2010term stability of attachment gain in infrabony defects (IBDs) 10\u2009years after regenerative treatment with an enamel matrix derivative (EMD) alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Two centres (Frankfurt [F] and Heidelberg [HD]) invited patients for re\u2010examination 120\u2009\u00b1\u200912\u2009months after regenerative therapy. Re\u2010examination included clinical examination (periodontal probing depths (PPD), vertical clinical attachment level (CAL), plaque index (PlI), gingival index (GI), plaque control record, gingival bleeding index and periodontal risk assessment) and review of patient charts (number of supportive periodontal care [SPC] visits).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both centres included 52 patients (29 female; median baseline age: 52.0\u2009years; lower\/upper quartile: 45.0\/58.8\u2009years; eight smokers), each contributing one IBD. Nine teeth were lost. For the remaining 43 teeth, regenerative therapy showed significant CAL gain after 1 year (3.0; 2.0\/4.4\u2009mm; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and 10 years (3.0; 1.5\/4.1\u2009mm; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) during which CAL remained stable (\u22120.5; \u22121.0\/1.0\u2009mm; <jats:italic>p<\/jats:italic>\u2009=\u20091.000) after an average SPC of 9\u2009years. Mixed\u2010model regression analyses revealed a positive association of CAL gain from 1 to 10\u2009years with CAL 12\u2009months post operation (logistic: <jats:italic>p<\/jats:italic>\u2009=\u2009.01) as well as a higher probability for CAL loss with an increasing vertical extent of a three\u2010walled defect component (linear: <jats:italic>p<\/jats:italic>\u2009=\u2009.008). Cox proportional hazard analysis showed a positive association between PlI after 12\u2009months and tooth loss (<jats:italic>p<\/jats:italic>\u2009=\u2009.046).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Regenerative therapy of IBDs showed stable results over 9\u2009years. CAL gain is associated with CAL after 12\u2009months and decreasing initial defect depth in a three\u2010walled defect morphology. Tooth loss is associated with PlI 12\u2009months post operation.<\/jats:p><jats:p><jats:bold>Clinical trial number:<\/jats:bold> DRKS00021148 (URL: <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/drks.de\">https:\/\/drks.de<\/jats:ext-link>).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13814","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T06:26:08Z","timestamp":1681367168000},"page":"996-1009","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long\u2010term stability of infrabony defects treated with enamel matrix derivative alone: A retrospective two\u2010centre cohort study"],"prefix":"10.1111","volume":"50","author":[{"given":"Ilona","family":"Koronna","sequence":"first","affiliation":[{"name":"Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum) Goethe University Frankfurt  Frankfurt Germany"},{"name":"Private Practice  Hanau Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beate","family":"Schacher","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum) Goethe University Frankfurt  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iulia","family":"Dahmer","sequence":"additional","affiliation":[{"name":"Institute of Biostatistics and Mathematical Modeling Goethe University Frankfurt  Frankfurt Germany"},{"name":"Center of Dentistry and Oral Medicine (Carolinum) Goethe University Frankfurt  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3785-8364","authenticated-orcid":false,"given":"Katrin","family":"Nickles","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum) Goethe University Frankfurt  Frankfurt Germany"},{"name":"Private Practice  Mannheim Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6062-1069","authenticated-orcid":false,"given":"Sarah K.","family":"Sonnenschein","sequence":"additional","affiliation":[{"name":"Section of Periodontology, Department of Conservative Dentistry, Clinic for Oral, Dental and Maxillofacial Diseases University Hospital Heidelberg  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ti\u2010Sun","family":"Kim","sequence":"additional","affiliation":[{"name":"Section of Periodontology, Department of Conservative Dentistry, Clinic for Oral, Dental and Maxillofacial Diseases University Hospital Heidelberg  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1655-8055","authenticated-orcid":false,"given":"Peter","family":"Eickholz","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum) Goethe University Frankfurt  Frankfurt Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8901-8017","authenticated-orcid":false,"given":"Hari","family":"Petsos","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Center for Dentistry and Oral Medicine (Carolinum) Goethe University Frankfurt  Frankfurt Germany"},{"name":"Private Practice  Butzbach Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,4,12]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13428"},{"key":"e_1_2_13_3_1","first-page":"229","article-title":"Problems and proposals for recording gingivitis and plaque","volume":"25","author":"Ainamo J.","year":"1975","journal-title":"International Dental Journal"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.1"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13302"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12638"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1993.64.4.261"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.9.797"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1995.66.4.261"},{"key":"e_1_2_13_10_1","first-page":"589","article-title":"The simplified papilla preservation flap. 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