{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T11:03:31Z","timestamp":1788260611275,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T00:00:00Z","timestamp":1682467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100016070","name":"ITI Foundation","doi-asserted-by":"publisher","award":["1365_2018"],"award-info":[{"award-number":["1365_2018"]}],"id":[{"id":"10.13039\/501100016070","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To investigate the spontaneous regeneration of the implanto\u2010mucosal and dento\u2010gingival unit after complete removal of keratinized tissue (KT).<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>One hemi\u2010mandible per dog (<jats:italic>n<\/jats:italic>\u2009=\u20094) was allocated to receive three dental implants (test sites, premolar region), whereas three premolars on the contralateral side were controls. After osseointegration, the entire KT (buccal + lingual) was surgically excised on all test and control sites, leaving the bone exposed. Clinical measurements were performed before excision (T<jats:sub>0<\/jats:sub>) and after 12\u2009weeks (T<jats:sub>1<\/jats:sub>). Following healing, the animals were euthanized, and the specimens were histologically processed. Descriptive statistical analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Clinical measurements revealed that at T<jats:sub>1<\/jats:sub>, on all teeth, a band of KT was spontaneously regenerated (mean width: 2.60\u2009\u00b1\u20090.66\u2009mm), whereas on implants, KT was detected only occasionally at mesial or distal but not at buccal sites (mean total: 0.35\u2009\u00b1\u20090.53\u2009mm; <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001). Histologically, spontaneous regeneration of the dento\u2010gingival unit was evident, displaying masticatory mucosa. At the implant sites, on the other hand, the implanto\u2010mucosal unit was characterized by a non\u2010keratinized epithelium and elastic fibres, indicating the characteristics encountered in alveolar mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>After excision of KT at implant sites, the spontaneous regeneration of the soft tissue is characterized by a non\u2010keratinized epithelium typical for alveolar mucosa, while at tooth sites the spontaneous regeneration was characterized by soft tissue resembling gingiva.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13820","type":"journal-article","created":{"date-parts":[[2023,4,26]],"date-time":"2023-04-26T09:15:03Z","timestamp":1682500503000},"page":"1064-1074","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Spontaneous regeneration of keratinized tissue at implants and teeth"],"prefix":"10.1111","volume":"50","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6690-5249","authenticated-orcid":false,"given":"Jean\u2010Claude","family":"Imber","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8079-0860","authenticated-orcid":false,"given":"Andrea","family":"Roccuzzo","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5631-3300","authenticated-orcid":false,"given":"Alexandra","family":"St\u00e4hli","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2132-6363","authenticated-orcid":false,"given":"Dieter D.","family":"Bosshardt","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4130-1526","authenticated-orcid":false,"given":"Fernando","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Department of Veterinary Clinical Sciences University of Santiago de Compostela, iBonelab SL  Lugo Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5110-2539","authenticated-orcid":false,"given":"Christoph A.","family":"Ramseier","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6938-9611","authenticated-orcid":false,"given":"Niklaus P.","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-5477","authenticated-orcid":false,"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine University of Bern  Bern Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,4,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1996.tb00520.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1991.020206.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.18-0031"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12185"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1977.48.3.140"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1979.50.1.1"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12419"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12150"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-020-03422-1"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.1975.46.10.577"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1975.tb00001.x"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0765.1971.tb00619.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2013.120688"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13673"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jper.18-0471"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13381"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13766"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13716"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/clr.12563"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12407"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.12206"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13194"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0501.1995.060301.x"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1983.tb01277.x"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1983.tb01275.x"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051x.1983.tb02208.x"}],"container-title":["Journal of Clinical Periodontology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jcpe.13820","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,13]],"date-time":"2023-09-13T08:27:38Z","timestamp":1694593658000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jcpe.13820"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,26]]},"references-count":27,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["10.1111\/jcpe.13820"],"URL":"https:\/\/doi.org\/10.1111\/jcpe.13820","archive":["Portico"],"relation":{},"ISSN":["0303-6979","1600-051X"],"issn-type":[{"value":"0303-6979","type":"print"},{"value":"1600-051X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,4,26]]},"assertion":[{"value":"2022-12-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}