{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T16:10:27Z","timestamp":1791216627849,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"S26","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J Clinic Periodontology"],"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of this systematic review was to evaluate the efficacy of patient\u2010performed or administered adjunctive measures to non\u2010surgical peri\u2010implantitis therapy in terms of probing depth (PD) and\/or bleeding on probing (BoP) reductions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Randomized and controlled clinical trials with at least 6\u2009months of follow\u2010up were searched in three databases. Secondary outcomes included implant loss, disease resolution, recurrence of peri\u2010implantitis, need of re\u2010treatment, changes in marginal bone levels, patient\u2010reported outcomes and adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 567 titles, 10 publications, reporting 9 investigations, were included. Three types of adjunctive measures were found (local\/systemic antimicrobials and probiotics). Four studies evaluated the effects of local antimicrobials (i.e., minocycline microspheres, chlorhexidine chips or a metronidazole + amoxicillin gel), three studies evaluated systemic antimicrobials (either amoxicillin + metronidazole or metronidazole alone) and two studies evaluated probiotics (<jats:italic>Lactobacillus reuteri<\/jats:italic> strains). The addition of local antimicrobials led to modest improvements in PD reduction. Systemic antimicrobials showed significantly greater reductions in PD and BoP, especially at initially deep sites (PD\u2009&gt;\u20096\u2009mm). Due to the large heterogeneity among included studies, no meta\u2010analyses were performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Different adjunctive measures in the non\u2010surgical treatment of peri\u2010implantitis have different impact in terms of PD and BoP reductions. Improved PD reductions result after the use of systemic antimicrobials, and to a lesser extent, after the use of local antimicrobials.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jcpe.13821","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T05:36:01Z","timestamp":1683264961000},"page":"224-243","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":58,"title":["Efficacy of adjunctive measures in the non\u2010surgical treatment of peri\u2010implantitis: A systematic review"],"prefix":"10.1111","volume":"50","author":[{"given":"Antonio","family":"Li\u00f1ares","sequence":"first","affiliation":[{"name":"Periodontology Unit, Faculty of Odontology University of Santiago de Compostela  Santiago de Compostela Spain"},{"name":"Medical\u2010Surgical Dentistry Research Group Health Research Institute of Santiago de Compostela  Santiago de Compostela 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